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Endosialin Expression in Metastatic Melanoma Tumor Microenvironment Vasculature: Potential Therapeutic Implications

Content Provider	Springer Nature Link
Author	Kiyohara, Eiji Donovan, Nicholas Takeshima, Ling Huang, Sharon Wilmott, James S. Scolyer, Richard A. Jones, Peter Somers, Elizabeth B. O’Shannessy, Daniel J. Hoon, Dave S. B.
Copyright Year	2015
Abstract	Ontuxizumab (MORAb-004) is a humanized recombinant antibody targeting endosialin (TEM-1, CD248). We conducted an analysis of endosialin expression in metastatic melanoma specimens using the anti-endosialin rat anti- MAb 9G5, in order to determine the potential of endosialin as a therapeutic target within the tumor microenvironment vasculature. Endosialin expression in paraffin-embedded archival tissue block (PEAT) melanoma tissues was assessed using immunohistochemistry (IHC) with the anti-endosialin, MAb 9G5, in the vessels of American Joint Commission on Cancer (AJCC) Stage III (n = 18) and Stage IV (n = 48) specimens. IHC for endosialin expression was further performed on a TMA that included 136 Stage IV and 33 paired Stage III melanoma specimens. BRAF mutation (mt) was also evaluated in individual melanoma specimens and as well as the TMA. Analysis showed 70 % of melanoma specimens (n = 46) were positive for endosialin expression. There was no significant difference in endosialin and BRAFmt expression between stages III vs. IV specimens. Endosialin expression was detected in 86 % (n = 117) of stage IV TMA specimens, while no expression was detected in 29 normal tissue controls. MAb 9G5 detects the presence of endosialin in the microenvironment tumor vasculature of most metastatic melanoma tissues, regardless of clinical stage and presence of BRAFmt. Endosialin may be a potential therapeutic target by virtue of its selective expression in metastatic melanoma relative to normal tissues.
Starting Page	111
Ending Page	118
Page Count	8
File Format	PDF
ISSN	18752292
Journal	Cancer Microenvironment
Volume Number	8
Issue Number	2
e-ISSN	18752284
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-06-18
Publisher Institution	International Cancer Microenvironment Society
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Melanoma Endosialin CD248 TEM-1 MAb 9G5 Cancer Research Oncology Immunology Cell Biology Biochemistry Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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