NDLI: Immunological Mechanisms of Low and Ultra-Low Dose Cancer Chemotherapy

Please wait, while we are loading the content...

Immunological Mechanisms of Low and Ultra-Low Dose Cancer Chemotherapy

Content Provider	Springer Nature Link
Author	Landreneau, Joshua P. Shurin, Michael R. Agassandian, Marianna V. Keskinov, Anton A. Ma, Yang Shurin, Galina V.
Copyright Year	2013
Abstract	Traditionally, anticancer chemotherapy has been generally considered to be strongly immunosuppressive. However, increasing evidence suggests that certain chemotherapeutic agents rely on the induction of antitumor immune responses, in both experimental animal models and patients with cancer. Many of these chemotherapeutic agents exert immunogenic effects via the induction and release of immunostimulatory “danger” signals from dying cancerous cells when used in low doses. New data suggests that several common chemotherapeutic agents may also display direct stimulating effects on immune cells even when applied in ultra-low concentrations (chemoimmunomodulation). Importantly, it is becoming clear that both immune effector cells and immune regulatory cells can be targeted by various chemotherapeutic agents to produce favorable antitumor immune responses. Therefore, utilizing cancer drugs to enhance host antitumor immunity should be considered a feasible therapeutic approach; and recent characterization of the immunomodulatory mechanisms of anticancer chemotherapy using both new and traditional cytotoxic agents suggests that combinations of these approaches with “classical” immunomodulatory agents could lead to a viable new therapeutic paradigm for the treatment of cancer.
Starting Page	57
Ending Page	64
Page Count	8
File Format	PDF
ISSN	18752292
Journal	Cancer Microenvironment
Volume Number	8
Issue Number	2
e-ISSN	18752284
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-11-29
Publisher Institution	International Cancer Microenvironment Society
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Chemotherapy Low dose chemotherapy Chemoimmunomodulation Tumor immunoenvironment Immunosuppression Immunotherapy Cancer therapy Immune regulators Cancer Research Oncology Immunology Cell Biology Biochemistry Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Immunological Mechanisms of Low and Ultra-Low Dose Cancer Chemotherapy.

Cancer as an immune-mediated disease

The Tumor Immunoenvironment

Systems Biology: A Therapeutic Target for Tumor Therapy

T Cell Avidity and Tumor Immunity: Problems and Solutions

The Role of Mast Cells in Molding the Tumor Microenvironment

Immunological Mechanisms of Low and Ultra-Low Dose Cancer Chemotherapy

Cancer-Immune Equilibrium: Questions Unanswered

Mechanisms of immune modulation in the tumor microenvironment and implications for targeted therapy.

Immunological Mechanisms of Low and Ultra-Low Dose Cancer Chemotherapy

Similar Documents

Immunological Mechanisms of Low and Ultra-Low Dose Cancer Chemotherapy.

Cancer as an immune-mediated disease

The Tumor Immunoenvironment

Systems Biology: A Therapeutic Target for Tumor Therapy

T Cell Avidity and Tumor Immunity: Problems and Solutions

The Role of Mast Cells in Molding the Tumor Microenvironment

Immunological Mechanisms of Low and Ultra-Low Dose Cancer Chemotherapy

Cancer-Immune Equilibrium: Questions Unanswered

Mechanisms of immune modulation in the tumor microenvironment and implications for targeted therapy.

Immunological Mechanisms of Low and Ultra-Low Dose Cancer Chemotherapy