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| Content Provider | Springer Nature Link |
|---|---|
| Author | Kitadai, Yasuhiko |
| Copyright Year | 2009 |
| Abstract | Recent studies in molecular and cellular biology have shown that tumor growth and metastasis are not determined by cancer cells alone but also by a variety of stromal cells. The stroma constitutes a large part of most solid tumors, and cancer-stromal cell interaction contributes functionally to tumor growth and metastasis. Angiogenesis is the result of an imbalance between positive and negative angiogenic factors released by tumor and host cells into the microenvironment of the neoplastic tissue. In gastric cancer, tumor cells and stromal cells produce various angiogenic factors, including vascular endothelial growth factor, interleukin-8, and platelet-derived endothelial cell growth factor. The microenvironment in the gastric mucosa may also influence the angiogenic phenotype of gastric cancer. Helicobacter pylori infection increases expression of several angiogenic factors by tumor cells. Activated fibroblasts and macrophages in tumor stroma also play an important role in angiogenesis and tumor progression. We review the current understanding of cancer-stromal cell interaction as it pertains to tumor angiogenesis in gastric cancer. |
| Starting Page | 109 |
| Ending Page | 116 |
| Page Count | 8 |
| File Format | |
| ISSN | 18752292 |
| Journal | Cancer Microenvironment |
| Volume Number | 3 |
| Issue Number | 1 |
| e-ISSN | 18752284 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2009-12-18 |
| Publisher Institution | International Cancer Microenvironment Society |
| Publisher Place | Dordrecht |
| Access Restriction | Subscribed |
| Subject Keyword | Gastric cancer Angiogenesis Tumor-stromal cell interaction Carcinoma-associated fibroblast (CAF) Tumor-associated fibroblast (TAM) Mesenchymal stem cell (MSC) Biomedicine general Biochemistry Cell Biology Immunology Oncology Cancer Research |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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