NDLI: Deciphering the Key Features of Malignant Tumor Microenvironment for Anti-cancer Therapy

Content Provider	Springer Nature Link
Author	Shang, Bingxue Zhang, Gaochuan Pan, Yanyan Zhou, Quansheng
Copyright Year	2012
Abstract	Tumor microenvironment (TME) is important in tumor development and may be a target for anti-cancer therapy. The genesis of TME is a dynamic process that is regulated by intrinsic and extrinsic factors and coordinated by multiple genes, cells, and signal pathways. Cancer anaerobic metabolism and various oncogenes may stimulate the genesis of TME. Tumor cells and cancer stem cells actively participate in the genesis of the cancer stem cell niche and tumor neovascularization, important in the initiation of the TME. Various cancer-associated stromal cells, derived niche factors, and tumor-associated macrophages may function as promoters in the genesis of the TME. Dicer1 gene-deleted stromal cells can induce generation of cancer stem cells and initiate tumorigenesis, suggesting that stromal cells also may promote the genesis of the TME. Therefore, the key features of TME include niche-driving oncogenes, cancer anaerobic metabolism, niche-driving cancer stem cells, neovascularization, tumor-associated inflammatory cells, and cancer-associated stromal cells. These features are potential targets for normalization of the malignant TME and effective anti-cancer therapy.
Starting Page	211
Ending Page	223
Page Count	13
File Format	PDF
ISSN	18752292
Journal	Cancer Microenvironment
Volume Number	5
Issue Number	3
e-ISSN	18752284
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-05-17
Publisher Institution	International Cancer Microenvironment Society
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Stem cell Niche Oncogene Metabolism Angiogenesis Stromal cells Oncology Cell Biology Biomedicine general Biochemistry Immunology Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Deciphering the Key Features of Malignant Tumor Microenvironment for Anti-cancer Therapy.

Bone Marrow Microenvironment and Tumor Progression

The Hemopoietic Stem Cell Niche Versus the Microenvironment of the Multiple Myeloma-Tumor Initiating Cell

Cancer-Stromal Cell Interaction and Tumor Angiogenesis in Gastric Cancer

Deciphering the Key Features of Malignant Tumor Microenvironment for Anti-cancer Therapy

Small But Mighty: Microparticles as Mediators of Tumor Progression

Shaping of NK Cell Responses by the Tumor Microenvironment

The Prometastatic Microenvironment of the Liver

The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment

Deciphering the Key Features of Malignant Tumor Microenvironment for Anti-cancer Therapy

Similar Documents

Deciphering the Key Features of Malignant Tumor Microenvironment for Anti-cancer Therapy.

Bone Marrow Microenvironment and Tumor Progression

The Hemopoietic Stem Cell Niche Versus the Microenvironment of the Multiple Myeloma-Tumor Initiating Cell

Cancer-Stromal Cell Interaction and Tumor Angiogenesis in Gastric Cancer

Deciphering the Key Features of Malignant Tumor Microenvironment for Anti-cancer Therapy

Small But Mighty: Microparticles as Mediators of Tumor Progression

Shaping of NK Cell Responses by the Tumor Microenvironment

The Prometastatic Microenvironment of the Liver

The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment

Deciphering the Key Features of Malignant Tumor Microenvironment for Anti-cancer Therapy