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A possible role of myristoylated alanine-rich C kinase substrate in endocytic pathway of Alzheimer’s disease

Neuroscience Bulletin : Volume 26, Issue 3, June 2010

Neuroscience Bulletin : Volume 26, Issue 2, April 2010

Neuroscience Bulletin : Volume 26, Issue 1, February 2010

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Neuroscience Bulletin : Volume 24

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A possible role of myristoylated alanine-rich C kinase substrate in endocytic pathway of Alzheimer’s disease

Content Provider	Springer Nature Link
Author	Su, Rui Han, Zhen Yun Fan, Ji Ping Zhang, Yun Ling
Copyright Year	2010
Abstract	It is believed that amyloid-β peptide (Aβ) plays a central role in the pathogenesis of Alzheimer’s disease (AD). Thus, the process of amyloid precursor protein (APP) cleavage is a key event and has raised much attention in the field of AD research. It is proposed that APP, β- and γ-secretases are all located on the lipid raft, and the meeting of them is an indispensable step for Aβ generation. Endocytosis can lead to clustering of APP, β- and γ-secretases from separate smaller lipid rafts into a larger one. On the other hand, for myristoylated alanine-rich C kinase substrate (MARCKS), phosphorylation by protein kinase C (PKC) or interaction with Ca$^{2+}$ can lead to its release from membrane into cytoplasm. This process induces the release of actins and phosphatidylinositol 4, 5-bisphosphate (PIP$_{2}$), which are important factors for endocytosis. Thus, the present review proposes that MARCKS may be implicated in Aβ generation, by modulating free PIP$_{2}$ level and actin movement, causing endocytosis.β淀粉样蛋白(amyloid β, Aβ)在阿尔茨海默病(Alzheimer’s disease, AD)的发病过程中的重要作用已为人熟知。淀粉样前体蛋白(amyloid precursor protein, APP)的水解过程也因此成为AD研究的重点。 APP、 β-和γ-分泌酶都位于脂筏上, 三者的相遇是产生Aβ 的必要步骤, 而胞吞作用则能使分布在微小脂筏上的APP、 β-和γ-分泌酶集中到较大的脂筏上。另一方面, 豆蔻酰化的富丙氨酸的蛋白激酶C的底物(myristoylated alanine-rich C kinase substrate, MARCKS)被蛋白激酶C磷酸化或与钙离子作用后, 会离开细胞膜进入细胞质, 进而引起在胞吞作用中起重要作用的肌动蛋白和4, 5-二磷酸肌醇(PIP$_{2}$)的释放。因此, 本文提出假说, 认为MARCKS通过调节自由态PIP$_{2}$ 的水平和肌动蛋白的运动, 引发胞吞作用, 进而在Aβ 的产生过程中起重要作用。
Starting Page	338
Ending Page	344
Page Count	7
File Format	PDF
ISSN	16737067
Journal	Neuroscience Bulletin
Volume Number	26
Issue Number	4
e-ISSN	19958218
Language	Chinese
Publisher	Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Publisher Date	2010-08-06
Publisher Place	Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Alzheimer’s disease endocytosis myristoylated alanine-rich C kinase substrate lipid raft phosphatidylinositol 4, 5-bisphosphate actin cytoskeleton Pain Medicine Neurology Anatomy Anesthesiology Human Physiology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Neuroscience Physiology Medicine

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A possible role of myristoylated alanine-rich C kinase substrate in endocytic pathway of Alzheimer’s disease

Actin filament assembly by myristoylated alanine-rich C kinase substrate-phosphatidylinositol-4,5-diphosphate signaling is critical for dendrite branching.

Myristoylated Alanine-rich C Kinase Substrate (MARCKS) Sequesters Spin-labeled Phosphatidylinositol 4,5-Bisphosphate in Lipid Bilayers

Myristoylated Alanine-rich C Kinase Substrate (MARCKS) Produces Reversible Inhibition of Phospholipase C by Sequestering Phosphatidylinositol 4,5-Bisphosphate in Lateral Domains

X MARCKS the spot: myristoylated alanine-rich C kinase substrate in neuronal function and disease

Involvement of protein kinase C ɛ in thyrotropin-releasing hormone-stimulated phosphorylation of the myristoylated alanine-rich C kinase substrate in rat pituitary clonal cells

Myristoylated alanine-rich C kinase substrate coordinates native TRPC1 channel activation by phosphatidylinositol 4,5-bisphosphate and protein kinase C in vascular smooth muscle

Spatiotemporal Interactions of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) Protein with the Actin Cytoskeleton and Exocytosis of Oxytocin upon Prostaglandin F2α Stimulation of Bovine Luteal Cells1

MARCKS (myristoylated alanine-rich protein kinase C substrate)

A possible role of myristoylated alanine-rich C kinase substrate in endocytic pathway of Alzheimer’s disease

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A possible role of myristoylated alanine-rich C kinase substrate in endocytic pathway of Alzheimer’s disease

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A possible role of myristoylated alanine-rich C kinase substrate in endocytic pathway of Alzheimer’s disease