NDLI: Long-Term Cognitive Improvement After Benfotiamine Administration in Patients with Alzheimer’s Disease

Content Provider	Springer Nature Link
Author	Pan, Xiaoli Chen, Zhichun Fei, Guoqiang Pan, Shumei Bao, Weiqi Ren, Shuhua Guan, Yihui Zhong, Chunjiu
Copyright Year	2016
Abstract	To date, we still lack disease-modifying therapies for Alzheimer’s disease (AD). Here, we report that long-term administration of benfotiamine improved the cognitive ability of patients with AD. Five patients with mild to moderate AD received oral benfotiamine (300 mg daily) over 18 months. All patients were examined by positron emission tomography with Pittsburgh compound B (PiB-PET) and exhibited positive imaging with β-amyloid deposition, and three received PiB-PET imaging at follow-up. The five patients exhibited cognitive improvement as assayed by the Mini-Mental Status Examination (MMSE) with an average increase of 3.2 points at month 18 of benfotiamine administration. The three patients who received follow-up PiB-PET had a 36.7% increase in the average standardized uptake value ratio in the brain compared with that in the first scan. Importantly, the MMSE scores of these three had an average increase of 3 points during the same period. Benfotiamine significantly improved the cognitive abilities of mild to moderate AD patients independently of brain amyloid accumulation. Our study provides new insight to the development of disease-modifying therapy.
Starting Page	591
Ending Page	596
Page Count	6
File Format	PDF
ISSN	16737067
Journal	Neuroscience Bulletin
Volume Number	32
Issue Number	6
e-ISSN	19958218
Language	English
Publisher	Springer Singapore
Publisher Date	2016-10-01
Publisher Place	Singapore
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Alzheimer’s disease Therapy Benfotiamine PiB-PET Amyloid deposition Neurosciences Human Physiology Anesthesiology Anatomy Neurology Pain Medicine
Content Type	Text
Resource Type	Article
Subject	Neuroscience Physiology Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Benfotiamine prevents increased β-amyloid production in HEK cells induced by high glucose

Long-Term Cognitive Improvement After Benfotiamine Administration in Patients with Alzheimer’s Disease

Monocytes and Alzheimer’s disease

Alzheimer’s disease: epidemiology, genetics, and beyond

Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer’s disease

Oxidative stress in Alzheimer’s disease

Cerebrospinal fluid biomarkers of Alzheimer’s disease

Mitochondrial dysfunction and cellular metabolic deficiency in Alzheimer’s disease

Clusterin in Alzheimer’s disease: a player in the biological behavior of amyloid-beta

Long-Term Cognitive Improvement After Benfotiamine Administration in Patients with Alzheimer’s Disease

Similar Documents

Benfotiamine prevents increased β-amyloid production in HEK cells induced by high glucose

Long-Term Cognitive Improvement After Benfotiamine Administration in Patients with Alzheimer’s Disease

Monocytes and Alzheimer’s disease

Alzheimer’s disease: epidemiology, genetics, and beyond

Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer’s disease

Oxidative stress in Alzheimer’s disease

Cerebrospinal fluid biomarkers of Alzheimer’s disease

Mitochondrial dysfunction and cellular metabolic deficiency in Alzheimer’s disease

Clusterin in Alzheimer’s disease: a player in the biological behavior of amyloid-beta

Long-Term Cognitive Improvement After Benfotiamine Administration in Patients with Alzheimer’s Disease