NDLI: MiR-137 and miR-491 Negatively Regulate Dopamine Transporter Expression and Function in Neural Cells

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Neuroscience Bulletin : Volume 33

Neuroscience Bulletin : Volume 32

Neuroscience Bulletin : Volume 32, Issue 6, December 2016

Special Topic on Mental Health and Addiction

MiR-137 and miR-491 Negatively Regulate Dopamine Transporter Expression and Function in Neural Cells

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Neuroscience Bulletin : Volume 32, Issue 5, October 2016

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MiR-137 and miR-491 Negatively Regulate Dopamine Transporter Expression and Function in Neural Cells

Content Provider	Springer Nature Link
Author	Jia, Xiaojian Wang, Feng Han, Ying Geng, Xuewen Li, Minghua Shi, Yu Lu, Lin Chen, Yun
Copyright Year	2016
Abstract	The dopamine transporter (DAT) is involved in the regulation of extracellular dopamine levels. A 40-bp variable-number tandem repeat (VNTR) polymorphism in the 3′-untranslated region (3′UTR) of the DAT has been reported to be associated with various phenotypes that are involved in the aberrant regulation of dopaminergic neurotransmission. In the present study, we found that miR-137 and miR-491 caused a marked reduction of DAT expression, thereby influencing neuronal dopamine transport. Moreover, the regulation of miR-137 and miR-491 on this transport disappeared after the DAT was silenced. The miR-491 seed region that is located on the VNTR sequence in the 3′UTR of the DAT and the regulatory effect of miR-491 on the DAT depended on the VNTR copy-number. These data indicate that miR-137 and miR-491 regulate DAT expression and dopamine transport at the post-transcriptional level, suggesting that microRNA may be targeted for the treatment of diseases associated with DAT dysfunction.
Starting Page	512
Ending Page	522
Page Count	11
File Format	PDF
ISSN	16737067
Journal	Neuroscience Bulletin
Volume Number	32
Issue Number	6
e-ISSN	19958218
Language	English
Publisher	Springer Singapore
Publisher Date	2016-09-15
Publisher Place	Singapore
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Dopamine transporter Solute carrier family 6 member 3 hsa-miR-137 hsa-miR-491-5p 3′-Untranslated region Variable-number tandem repeat Posttranscriptional regulation Neurosciences Human Physiology Anesthesiology Anatomy Neurology Pain Medicine
Content Type	Text
Resource Type	Article
Subject	Neuroscience Physiology Medicine

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