NDLI: A Collaborative Nationwide Lymphoma Study in Lebanon: Incidence of Various Subtypes and Analysis of Associations with Viruses

Content Provider	Springer Nature Link
Author	Otrock, Zaher K. Saab, Jad Aftimos, Georges Nasr, Fady Farhat, Fadi S. Khairallah, Saad Abadjian, Gérard Ghosn, Marwan Sidani, Hassan Ibrahim, Ahmad Tawil, Ayman Ghorra, Claude Meguerian, Zarouhie Mokaddem, Walid Dayeh, Walid Salem, Ziad Chahine, Georges Bitar, Nizar Mugharbel, Anas Makdessi, Joseph Khater, Christina Hajj, Mirna Abi Gerges, Dany Sfeir, Charles Kattan, Joseph Ibrahim, Khaled Saade, Michel Sadek, Hussein Mahfouz, Rami A. Kharfan Dabaja, Mohamed A. Zaatari, Ghazi Bazarbachi, Ali
Copyright Year	2013
Abstract	Incidence of various Hodgkin (HL) and non-Hodgkin lymphoma (NHL) subtypes and association with viruses in Lebanon are not known. We undertook a nationwide study of 272 patients diagnosed with lymphoma in 2007. HL comprised 32.7 % (n = 89) of cases while NHL represented 67.3 % (n = 183). Consistent with the literature, nodular sclerosis was the most predominant HL subtype (n = 57/89). Among NHL, B-cell NHL represented 88 % (n = 161/183), T-cell NHL 9 % (n = 17/183), whereas in 2.7 % it was not classifiable. The B-cell NHL comprised predominantly diffuse large B-cell lymphoma (46 %) and follicular lymphoma (23 %). 81 cases were reviewed by a panel of pathologists with 87.6 % concordance rate. Serology was negative for hepatitis C in 122 tested cases. HIV was positive in 2 cases. Two adult T-cell leukemia/lymphoma were HTLV-I positive. EBV IgG were positive in 88.5 % of cases. 38 EBV seropositive cases [27 NHL (24 B-cell, 3 T-cell) and 11 HL] were studied for EBV genome expression using EBV-encoded RNA (EBER)-in situ hybridization. EBER expression was positive in 8 (21 %) cases (6 HL, 2 T-cell NHL). The distribution of lymphoma subtypes in Lebanon appears similar to that of Western countries. The high rate of EBV positivity in HL and T-cell lymphoma by EBER deserves further investigation.
Starting Page	715
Ending Page	722
Page Count	8
File Format	PDF
ISSN	12194956
Journal	Pathology & Oncology Research
Volume Number	19
Issue Number	4
e-ISSN	15322807
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-05-08
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Lymphoma Incidence Subtypes Viruses EBV Lebanon Cancer Research Oncology Pathology Immunology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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