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| Content Provider | Springer Nature Link |
|---|---|
| Author | Huang, Guo Liang Qiu, Jin Hua Li, Bin Bin Wu, Jing Jing Lu, Yan Liu, Xing Yan He, Zhiwei |
| Copyright Year | 2013 |
| Abstract | Pin1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1) plays a key role in a number of diseases including cancer and Alzheimer disease. Previous studies have identified a wide range of phosphoproteins as Pin1 substrates. Related pathways were analyzed separately. The aim of this study was to provide a comprehensive picture involving Pin1 regulation. A genome-wide mRNA expression microarray was carried out using the RNA isolation from Pin1 $^{+/+}$ and Pin1 $^{−/−}$ mouse embryonic fibroblast (MEF) cells. Signaling pathways regulated by Pin1 were analyzed with the utility of KEGG pathway and GO annotation. An expression pattern regulated by Pin1 was revealed. A total of 606 genes, 375 being up-regulated and 231 down-regulated, were differentially expressed when comparing Pin1 +/+ to Pin1 −/− MEF cells. Totally 48 pathways were shown to be regulated by Pin1 expression in KEGG pathway analysis. In the GO annotation system, 19 processes on biological processes, 15 processes on cellular components, and 18 processes on molecular functions were found to be in the regulation of Pin1 expression. Pathways related to immune system and cancer showed most significant association with Pin1 regulation. Pin1 is an important regulator in a wide range of signaling pathways that were related to immune system and cancer. |
| Starting Page | 667 |
| Ending Page | 675 |
| Page Count | 9 |
| File Format | |
| ISSN | 12194956 |
| Journal | Pathology & Oncology Research |
| Volume Number | 19 |
| Issue Number | 4 |
| e-ISSN | 15322807 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2013-04-08 |
| Publisher Place | Dordrecht |
| Access Restriction | Subscribed |
| Subject Keyword | Pin1 Pathway Cancer Immune Cancer Research Oncology Pathology Immunology Biomedicine general |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Pathology and Forensic Medicine Oncology |
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