NDLI: Down-Regulated Expression of HSP70 in Correlation with Clinicopathology of Cholangiocarcinoma

Content Provider	Springer Nature Link
Author	Boonjaraspinyo, Sirintip Boonmars, Thidarut Kaewkes, Sasithorn Laummaunwai, Porntip Pinlaor, Somchai Loilome, Watchalin Yongvanit, Puangrat Wu, Zhiliang Puapairoj, Anucha Bhudhisawasdi, Vajarabhongsa
Copyright Year	2011
Abstract	Cholangiocarcinoma is a crucial health problem in northeast Thailand. Although rare, it is a highly fatal disease and the prognosis of CCA patients is very poor. To determine if expression of specific genes is useful for diagnosis and prognosis for CCA. We examined the expression of HSP70, HSP90, RB1, cyclin D1, and HDAC6 in 50 resections of human CCA tissues by quantitative real-time PCR. The expression of HSP70, RB1, and HDAC6 was “dominant down-regulation,” while the expression of cyclin D1 and HSP90 was “dominant up-regulation.” There were no correlations between RB1, cyclin D1, HSP90, and clinicopathological parameters such as status, histology type, histological grading, stage of CCA, and metastasis. A significant association was found between HDAC6 and CCA staging (p = 0.000), CCA gross type and HSP70 (p = 0.046) as well as RB1 expression (p = 0.046). Patients with down-regulation of HSP70 had significantly poorer prognosis than those in the up-regulation group (p = 0.002). Expression of HSP70 may be useful as a new prognostic marker for CCA.
Starting Page	227
Ending Page	237
Page Count	11
File Format	PDF
ISSN	12194956
Journal	Pathology & Oncology Research
Volume Number	18
Issue Number	2
e-ISSN	15322807
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-07-13
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Cholangiocarcinoma Clinicopathology Retinoblastoma 1 Cyclin D1 Heat shock protein 70 Heat shock protein 90 Histone deacetylase 6 Biomedicine general Immunology Oncology Cancer Research Pathology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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