NDLI: A New Rapid Technique for the Fixation of Thyroid Gland Surgical Specimens

Content Provider	Springer Nature Link
Author	Rath Wolfson, Lea Koren, Rumelia Yaniv, Eitan Sadov, Rima Gal, Rivka
Copyright Year	1999
Abstract	One of the main diagnostic problems in thyroid pathology is to distinguish between follicular adenoma and follicular carcinoma. Thorough sampling of the nodule’s capsule is recommended in order to identify capsular invasion. However, during the hardening of the tissue, by the usual fixatives the capsule shrinks and rolls downwards and sometimes the capsule separates from the remaining tissue. The present work evaluates the use of “Lymph Node Revealing Solution” (LNRS) for the rapid fixation of different thyroid lesions as compared to that of formalin. Fifty-one unselected consecutive cases of thyroid nodules, which included various benign and malignant lesions, were examined. Each specimen was cut in two equal parts; one was fixed in LNRS, the other in formalin. Fixation in LNRS for 2 hours gave adequate results in sectioning and staining of the tissue, and excellent immunostains. Its advantage over formalin is the conservation of the natural relationship between the capsule and the rest of the tissue, on the same plane, as well as the short time required for the final diagnosis.
Starting Page	70
Ending Page	72
Page Count	3
File Format	PDF
ISSN	12194956
Journal	Pathology & Oncology Research
Volume Number	5
Issue Number	1
Language	English
Publisher	Springer Netherlands
Publisher Date	1999-01-01
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	lymph node revealing solution thyroid fixation Cancer Research Oncology Pathology Immunology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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