NDLI: Immunophenotyping of tumor-infiltrating mononuclear cells in ovarian carcinoma

Content Provider	Springer Nature Link
Author	Helal, Thanaa El A Alla, Ali E Khalf Laban, Mohamed A Fahmy, Remon M
Copyright Year	2004
Abstract	Infiltrating mononuclear cells play an important role in many types of cancer. The aim of this work was to determine the immunologic characteristics of mononuclear cellular infiltrate in ovarian cancer as compared to benign ovarian tumors. Paraffin-embedded tissues obtained from 52 ovarian carcinomas and 21 benign ovarian neoplasms were examined immunohistochemically to demonstrate suppressor/cytotoxic T cells and macrophages by using CD8 and CD68 monoclonal antibodies, respectively. The mean percentage of CD8+ cells was much higher in the malignant than in the benign group (P=0.00009). Similarly, the mean level of CD68+ cells was significantly higher in carcinomas than in benign cases (P=0.006). There was a significant negative correlation between the percentage of CD8+ cells and CD68+ cells in the malignant group (P=0.000002). Conversely, no correlation could be obtained between the values of these two cell types in the benign lesions. In the malignant group, although the percentages of CD8+ cells and CD68+ cells were not related to tumor differentiation, they were significantly related to tumor type. CD8+ cells were significantly higher in the serous (P=0.02), and CD68+ cells were higher in the mucinous carcinomas (P=0.0005). CD8+ T cells and macrophages constitute a major component of the infiltrating mononuclear cells in ovarian carcinoma. Their frequency seems to be related to the tumor type rather than the degree of tumor differentiation. (Pathology Oncology Research Vol 10, No 2, 80–84)
Starting Page	80
Ending Page	84
Page Count	5
File Format	PDF
ISSN	12194956
Journal	Pathology & Oncology Research
Volume Number	10
Issue Number	2
e-ISSN	15322807
Language	English
Publisher	Springer Netherlands
Publisher Date	2004-01-01
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Ovarian cancer benign ovarian tumors CD8+ cells CD68+ cells Cancer Research Oncology Pathology Immunology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Tumor-infiltrating B cell immunoglobulin variable region gene usage in invasive ductal breast carcinoma

Immunophenotyping of tumor-infiltrating mononuclear cells in ovarian carcinoma

PAX2, PAX8 and CDX2 Expression in Metastatic Mucinous, Primary Ovarian Mucinous and Seromucinous Tumors and Review of the Literature

Intra-tumoral cytolytic cells: Pattern of distribution in B-cell non Hodgkin’s lymphoma

Epidermoid carcinoma arising in Warthin’s tumor

The nested variant of urothelial carcinoma: an aggressive tumor closely simulating benign lesions

Expression of the TRAIL receptors in blood mononuclear cells in leukemia

Tumor stem cells

Parkin Gene Alterations in Ovarian Carcinoma from Northern Indian Population

Immunophenotyping of tumor-infiltrating mononuclear cells in ovarian carcinoma

Similar Documents

Tumor-infiltrating B cell immunoglobulin variable region gene usage in invasive ductal breast carcinoma

Immunophenotyping of tumor-infiltrating mononuclear cells in ovarian carcinoma

PAX2, PAX8 and CDX2 Expression in Metastatic Mucinous, Primary Ovarian Mucinous and Seromucinous Tumors and Review of the Literature

Intra-tumoral cytolytic cells: Pattern of distribution in B-cell non Hodgkin’s lymphoma

Epidermoid carcinoma arising in Warthin’s tumor

The nested variant of urothelial carcinoma: an aggressive tumor closely simulating benign lesions

Expression of the TRAIL receptors in blood mononuclear cells in leukemia

Tumor stem cells

Parkin Gene Alterations in Ovarian Carcinoma from Northern Indian Population

Immunophenotyping of tumor-infiltrating mononuclear cells in ovarian carcinoma