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| Content Provider | Springer Nature Link |
|---|---|
| Author | Perambakam, Supriya Naresh, K. Nerurkar, Ashutosh Nadkarni, Jayshree |
| Copyright Year | 2000 |
| Abstract | Non-Hodgkin’s lymphomas (NHLs) constitute a heterogeneous group of lymphoid neoplasms and a majority of them in India are of B-cell phenotype. Varying numbers of T lymphocytes and natural killer (NK) cells are consistently present within the lymph nodes (LNs). The role of these “reactive” cells is becoming understood. TIA-1 is a cytotoxic granule associated RNA binding protein, the expression of which is restricted to cytotoxic T lymphocytes (CTLs) and NK cells. Snap frozen lymph node biopsies obtained from 41 B-cell NHLs were localized for intra-tumoral TIA-1 + cytolytic cells by immunohistochemistry. Distribution of T cell subsets and NK cells were also quantified. Cells expressing TIA-1 antigen was observed in all the cases, seen as a strong granular cytoplasmic signal. Results indicate significantly higher number of TIA-1 cytolytic cells outside (periphery of the follicle and interfollicular areas) than within the neoplastic follicle in follicular lymphomas (p<0.001). In small lymphocytic lymphomas, cytolytic cells were mainly seen as uniformly scattered single cells, distributed throughout the tumor environment. In mantle cell and diffuse large B-cell lymphomas these were most often seen as small clusters and less frequently as singly scattered cells. Higher numbers of CD4$^{+}$ than the CD8$^{+}$ T cells were observed in most cases. Contrary to the follicles in follicular hyperplasia, CD57$^{+}$ NK cells were predominantly observed outside the neoplastic follicle in follicular lymphomas (FLs). These results outline specific interactions between the potential antitumoral cytolytic and the malignant cells of B-cell NHLs. |
| Starting Page | 114 |
| Ending Page | 117 |
| Page Count | 4 |
| File Format | |
| ISSN | 12194956 |
| Journal | Pathology & Oncology Research |
| Volume Number | 6 |
| Issue Number | 2 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2000-01-01 |
| Publisher Place | Dordrecht |
| Access Restriction | Subscribed |
| Subject Keyword | lymphoma T-cells CD4 CD8 TIA-1 NK cells tumor infiltrating lymphocytes cytotoxic cells B-cell Cancer Research Oncology Pathology Immunology Biomedicine general |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Pathology and Forensic Medicine Oncology |
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