NDLI: The herpes simplex virus type 1 infected cell protein 22

Content Provider	Springer Nature Link
Author	Lin, Fu sen Ding, Qiong Guo, Hong Zheng, Alan C.
Copyright Year	2010
Abstract	As one of the immediate-early (IE) proteins of herpes simplex virus type 1 (HSV-1), ICP22 is a multifunctional viral regulator that localizes in the nucleus of infected cells. It is required in experimental animal systems and some nonhuman cell lines, but not in Vero or HEp-2 cells. ICP22 is extensively phosphorylated by viral and cellular kinases and nucleotidylylated by casein kinase II. It has been shown to be required for efficient expression of early (E) genes and a subset of late (L) genes. ICP22, in conjunction with the UL13 kinase, mediates the phosphorylation of RNA polymerase II. Both ICP22 and UL13 are required for the activation of cdc2, the degradation of cyclins A and B and the acquisition of a new cdc2 partner, the UL42 DNA polymerase processivity factor. The cdc2-UL42 complex mediates postranscriptional modification of topoisomerase IIα in an ICP22-dependent manner to promote L gene expression. In addition, ICP22 interacts with cdk9 in a Us3 kinase dependent fashion to phosphorylate RNA polymerase II.
Starting Page	1
Ending Page	7
Page Count	7
File Format	PDF
ISSN	16740769
Journal	Virologica Sinica
Volume Number	25
Issue Number	1
e-ISSN	1995820X
Language	English
Publisher	SP Wuhan Institute of Virology, CAS
Publisher Date	2010-02-12
Publisher Place	Heidelberg
Access Restriction	Subscribed
Subject Keyword	Herpes Simplex Virus type 1(HSV-1) ICP22 UL13 Microbial Genetics and Genomics Microbiology Biochemistry Oncology Medical Microbiology Virology
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Virology Immunology Molecular Medicine

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