NDLI: Immunogenicity of the spike glycoprotein of Bat SARS-like coronavirus

Content Provider	Springer Nature Link
Author	Hou, Yu xuan Peng, Cheng Han, Zheng gang Zhou, Peng Chen, Ji guo Shi, Zheng li
Copyright Year	2010
Abstract	A group of SARS-like coronaviruses (SL-CoV) have been identified in horseshoe bats. Despite SL-CoVs and SARS-CoV share identical genome structure and high-level sequence similarity, SL-CoV does not bind to the same cellular receptor as for SARS-CoV and the N-terminus of the S proteins only share 64% amino acid identity, suggesting there are fundamental differences between these two groups of coronaviruses. To gain insight into the basis of this difference, we established a recombinant adenovirus system expressing the S protein from SL-CoV (rAd-Rp3-S) to investigate its immune characterization. Our results showed that immunized mice generated strong humoral immune responses against the SL-CoV S protein. Moreover, a strong cellular immune response demonstrated by elevated IFN-γ and IL-6 levels was also observed in these mice. However, the induced antibody from these mice had weaker cross-reaction with the SARS-CoV S protein, and did not neutralize HIV pseudotyped with SARS-CoV S protein. These results demonstrated that the immunogenicity of the SL-CoV S protein is distinct from that of SARS-CoV, which may cause the immunological differences between human SARS-CoV and bat SL-CoV. Furthermore, the recombinant virus could serve as a potential vaccine candidate against bat SL-CoV infection.
Starting Page	36
Ending Page	44
Page Count	9
File Format	PDF
ISSN	16740769
Journal	Virologica Sinica
Volume Number	25
Issue Number	1
e-ISSN	1995820X
Language	English
Publisher	SP Wuhan Institute of Virology, CAS
Publisher Date	2010-02-12
Publisher Place	Heidelberg
Access Restriction	Subscribed
Subject Keyword	SARS coronavirus (SARS-CoV) SARS-like coronavirus (SL-CoV) Spike glycoprotein Humoral immune response Cellular immune response Microbial Genetics and Genomics Microbiology Biochemistry Oncology Medical Microbiology Virology
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Virology Immunology Molecular Medicine

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