NDLI: Molecular characterization of China human rabies vaccine strains

Content Provider	Springer Nature Link
Author	Tao, Xiaoyan Han, Na Guo, Zhenyang Tang, Qing Rayner, Simon Liang, Guodong
Copyright Year	2013
Abstract	To understand the molecular characteristics of China human rabies vaccine strains, we report the full-length genome of the aG strain and present a comprehensive analysis of this strain and almost all available lyssavirus genomes (58 strains) from GenBank (as of Jan 6, 2011). It is generally considered that the G protein plays a predominant role in determining the pathogenicity of the virus, to this end we predicted the tertiary structure of the G protein of aG strain, CTN181 strain and wild type strain HN10 based on the crystal structure of Vesicular stomatitis virus (VSV) G. The predicted RABV G structure has a similar topology to VSV G and the ectodomain can be divided into 4 distinct domains DI — DIV. By mapping the characterized mutations to this structure between China vaccine strains and their close street strains, we speculate that the G303(P-H) mutations of CTN181 and HN10 causing DII 3D change may be associated with the II attenuated virulence in both strains. Specifically, the two signature mutations (G165P and G231P) in the aG strain are withinßsheets, suggesting that both sites are of structural importance.
Starting Page	116
Ending Page	123
Page Count	8
File Format	PDF
ISSN	16740769
Journal	Virologica Sinica
Volume Number	28
Issue Number	2
e-ISSN	1995820X
Language	English
Publisher	SP Wuhan Institute of Virology, CAS
Publisher Date	2013-04-11
Publisher Place	Heidelberg
Access Restriction	Subscribed
Subject Keyword	Rabies virus Lyssavirus Genome Glycoprotein Virology Medical Microbiology Oncology Biochemistry Microbiology Microbial Genetics and Genomics
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Virology Immunology Molecular Medicine

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