NDLI: Human Health Relevance of Pharmaceutically Active Compounds in Drinking Water

Content Provider	Springer Nature Link
Author	Khan, Usman Nicell, Jim
Copyright Year	2015
Abstract	In Canada, as many as 20 pharmaceutically active compounds (PhACs) have been detected in samples of treated drinking water. The presence of these PhACs in drinking water raises important questions as to the human health risk posed by their potential appearance in drinking water supplies and the extent to which they indicate that other PhACs are present but have not been detected using current analytical methods. Therefore, the goal of the current investigation was to conduct a screening-level assessment of the human health risks posed by the aquatic release of an evaluation set of 335 selected PhACs. Predicted and measured concentrations were used to estimate the exposure of Canadians to each PhAC in the evaluation set. Risk evaluations based on measurements could only be performed for 17 PhACs and, of these, all were found to pose a negligible risk to human health when considered individually. The same approach to risk evaluation, but based on predicted rather than measured environmental concentrations, suggested that 322 PhACs of the evaluation set, when considered individually, are expected to pose a negligible risk to human health due to their potential presence in drinking waters. However, the following 14 PhACs should be prioritized for further study: triiodothyronine, thyroxine, ramipril and its metabolite ramiprilat, candesartan, lisinopril, atorvastatin, lorazepam, fentanyl, atenolol, metformin, enalaprilat, morphine, and irbesartan. Finally, the currently available monitoring data for PhACs in Canadian surface and drinking waters was found to be lacking, irrespective of whether their suitability was assessed based on risk posed, predicted exposure concentrations, or potency.
Starting Page	558
Ending Page	585
Page Count	28
File Format	PDF
ISSN	12341234
Journal	The AAPS Journal
Volume Number	17
Issue Number	3
e-ISSN	15507416
Language	English
Publisher	Springer US
Publisher Date	2015-03-05
Publisher Institution	American Association of Pharmaceutical Scientists
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Pharmacology/Toxicology Biochemistry Biotechnology Pharmacy
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

How Promiscuous Are Pharmaceutically Relevant Compounds? A Data-Driven Assessment

Human Health Relevance of Pharmaceutically Active Compounds in Drinking Water

Impact of Epigenetic Dietary Compounds on Transgenerational Prevention of Human Diseases

Approaches to the Development of Human Health Toxicity Values for Active Pharmaceutical Ingredients in the Environment

Lateral Drug Diffusion in Human Nails

Covariate Pharmacokinetic Model Building in Oncology and its Potential Clinical Relevance

Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes

Transdermal Absorption Enhancement of Rice Bran Bioactive Compounds Entrapped in Niosomes

Applications of Human Pharmacokinetic Prediction in First-in-Human Dose Estimation

Human Health Relevance of Pharmaceutically Active Compounds in Drinking Water

Similar Documents

How Promiscuous Are Pharmaceutically Relevant Compounds? A Data-Driven Assessment

Human Health Relevance of Pharmaceutically Active Compounds in Drinking Water

Impact of Epigenetic Dietary Compounds on Transgenerational Prevention of Human Diseases

Approaches to the Development of Human Health Toxicity Values for Active Pharmaceutical Ingredients in the Environment

Lateral Drug Diffusion in Human Nails

Covariate Pharmacokinetic Model Building in Oncology and its Potential Clinical Relevance

Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes

Transdermal Absorption Enhancement of Rice Bran Bioactive Compounds Entrapped in Niosomes

Applications of Human Pharmacokinetic Prediction in First-in-Human Dose Estimation

Human Health Relevance of Pharmaceutically Active Compounds in Drinking Water