NDLI: Effect of radiation therapy on small-cell lung cancer is reduced by ubiquinone intake

Content Provider	Springer Nature Link
Author	Lund, E. L. Quistorff, B. Spang Thomsen, M. Kristjansen, P. E. G.
Copyright Year	1998
Abstract	The effect of oral ubiquinone (Q$_{10}$) intake on thein vivo response of tumors to single dose radiotherapy was examined. The human small-cell lung cancer (SCLC) line CPH 054A, which is sensitive to relatively low doses of X-radiation, was grown as subcutaneous transplants in the flanks of nude nu/nu mice. When macroscopical growth was established, groups of mice received either 10, 20 or 40 mg/kg Q$_{10}$ in 30 mL soy oil intragastrically daily on 4 consecutive days. Controls received either 30 mL of pure soy oil or nothing. Three h after the last dose half of the tumors in each group received a single radiation dose of 5 Gy, using a 300 kV therapeutic unit. The macroscopic growth pre- and posttreatment was analyzed according to a transformed Gompertz algorithm using the software program GROWTH. Treatment with Q$_{10}$ or soy oil alone had no effect on tumor growth compared with untreated controls. Groups of tumors that received Q$_{10}$ and radiotherapy had a significantly lower specific growth delay (SGD) than the radiotherapy-only groups. This effect was significant at 40 mg/kg and borderline at 20 mg/kg, whereas at 10 mg/kg no radioprotection was seen. We conclude that systemic Q$_{10}$ reduces the response to single dose tumor irradiation inxenotransplanted human SCLC tumors.
Starting Page	505
Ending Page	506
Page Count	2
File Format	PDF
ISSN	00155632
Journal	Folia Microbiologica
Volume Number	43
Issue Number	5
e-ISSN	18749356
Language	English
Publisher	Springer Netherlands
Publisher Date	1998-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Life Sciences Microbiology Applied Microbiology Immunology Environmental Engineering/Biotechnology
Content Type	Text
Resource Type	Article
Subject	Medicine Microbiology

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