NDLI: Synthetic molecules: helping to unravel plant signal transduction

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Synthetic molecules: helping to unravel plant signal transduction

Content Provider	Springer Nature Link
Author	Xuan, Wei Murphy, Evan Beeckman, Tom Audenaert, Dominique De Smet, Ive
Copyright Year	2013
Abstract	The application of small molecules has played a crucial role in identifying novel components involved in plant signalling. Compared to classic genetic approaches, small molecule screens offer notable advantages in dissecting plant biological processes, such as technical simplicity, low start-up costs, and most importantly, bypassing the problems of lethality and redundancy. To identify small molecules that target a biological process or protein of interest, robust and well-reasoned high-throughput screening approaches are essential. In this review, we present a series of principles and valuable approaches in small molecule screening in the plant model system Arabidopsis thaliana. We also provide an overview of small molecules that led to breakthroughs in uncovering phytohormone signalling pathways, endomembrane signalling cascades, novel growth regulators, and plant defence mechanisms. Meanwhile, the strategies to deciphering the mechanisms of these small molecules on Arabidopsis are highlighted. Moreover, the opportunities and challenges of small molecule applications in translational biology are discussed.
Starting Page	43
Ending Page	50
Page Count	8
File Format	PDF
ISSN	18646158
Journal	Journal of Chemical Biology
Volume Number	6
Issue Number	2
e-ISSN	18646166
Language	English
Publisher	Springer-Verlag
Publisher Date	2013-03-03
Publisher Place	Berlin, Heidelberg
Access Restriction	Subscribed
Subject Keyword	Chemical biology Plant growth and development Small molecules Screening Translational biology Physical Chemistry Biophysics and Biological Physics Cell Biology Pharmacology/Toxicology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Biophysics

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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