NDLI: EU-OPENSCREEN—chemical tools for the study of plant biology and resistance mechanisms

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EU-OPENSCREEN—chemical tools for the study of plant biology and resistance mechanisms

Content Provider	Springer Nature Link
Author	Meiners, Torsten Stechmann, Bahne Frank, Ronald
Copyright Year	2014
Abstract	EU-OPENSCREEN is an academic research infrastructure initiative in Europe for enabling researchers in all life sciences to take advantage of chemical biology approaches to their projects. In a collaborative effort of national networks in 16 European countries, EU-OPENSCREEN will develop novel chemical compounds with external users to address questions in, among other fields, systems and network biology (directed and selective perturbation of signalling pathways), structural biology (compound-target interactions at atomic resolution), pharmacology (early drug discovery and toxicology) and plant biology (response of wild or crop plants to environmental and agricultural substances). EU-OPENSCREEN supports all stages of a tool development project, including assay adaptation, high-throughput screening and chemical optimisation of the ‘hit’ compounds. All tool compounds and data will be made available to the scientific community. EU-OPENSCREEN integrates high-capacity screening platforms throughout Europe, which share a rationally selected compound collection comprising up to 300,000 (commercial and proprietary compounds collected from European chemists). By testing systematically this chemical collection in hundreds of assays originating from very different biological themes, the screening process generates enormous amounts of information about the biological activities of the substances and thereby steadily enriches our understanding of how and where they act.
Starting Page	113
Ending Page	118
Page Count	6
File Format	PDF
ISSN	18646158
Journal	Journal of Chemical Biology
Volume Number	7
Issue Number	4
e-ISSN	18646166
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-07-31
Publisher Place	Berlin, Heidelberg
Access Restriction	Subscribed
Subject Keyword	High-capacity screening European research infrastructure Tool development Compound collection Open access Biological assays Physical Chemistry Biophysics and Biological Physics Cell Biology Pharmacology/Toxicology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Biophysics

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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