NDLI: Analysis of organic gunshot residue permeation through a model skin membrane using ion mobility spectrometry

Content Provider	Springer Nature Link
Author	Moran, Jordan Bell, Suzanne
Copyright Year	2013
Abstract	Identification and detection of gunshot residue (GSR) is useful in firearm related events and provides important evidence in trials and related cases. At present, methodologies based on the analysis of inorganic particles found in GSR are not amenable to rapid presumptive testing in the field or laboratory settings. An alternative is to target the organic analytes that are vaporized during the firing event and then re-condense on skin and other surfaces, such as clothing. Previous studies have demonstrated that the persistence of organic compounds, such as diphenylamine (DPA), from hand swabs of shooters as detected using commercial ion mobility spectrometry (IMS) instruments was 3–4 h. These same studies indicated that secondary transfer did not occur, which implied that losses of the organic compounds were attributable to absorption into the skin. The goal of this study was to assess the dermal absorption characteristics of organic gunshot residue (OGSR) using IMS. Two studies were conducted. First, a qualitative IMS method was developed for the in vitro analysis of select OGSR compounds. In vitro studies with medical grade silicone were conducted using Franz diffusion cells (FDCs). The results from this study demonstrated that OGSR was dermally absorbed. Second, a semi-quantitative IMS method was developed for an in vitro study of DPA. The skin permeability of DPA (K$_{p}$) was experimentally determined to be 2.6 × 10$^{−2}$ cm/hr, the steady state flux (J$_{ss}$) was 13 μg cm$^{−2}$ hr$^{−1}$, and the lag time was 8.9 h. The results show excellent correlation with the 3–4 h persistence previously reported.
Starting Page	247
Ending Page	258
Page Count	12
File Format	PDF
ISSN	14356163
Journal	International Journal for Ion Mobility Spectrometry
Volume Number	16
Issue Number	4
e-ISSN	18654584
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-06-01
Publisher Place	Berlin, Heidelberg
Access Restriction	Subscribed
Subject Keyword	Forensic science Organic gunshot residue Skin permeation Ion mobility spectrometry Analytical Chemistry Physical Chemistry Molecular Medicine Proteomics Ecotoxicology Safety in Chemistry, Dangerous Goods
Content Type	Text
Resource Type	Article
Subject	Spectroscopy

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Transport modeling of membrane extraction of chlorinated hydrocarbon from water for ion mobility spectrometry

Medical applications of ion mobility spectrometry

Hydrocarbon detection using laser ion mobility spectrometry

Ion mobility spectrometry: a personal retrospective

Ion mobility spectrometer—field asymmetric ion mobility spectrometer-mass spectrometry

Alexandre A. Svartsburg: Differential Ion Mobility Spectrometry

Minimal retarded Propofol signals in human breath using ion mobility spectrometry

Subambient pressure electrospray ionization ion mobility spectrometry

An NO$^{+}$ reactant ion source for ion mobility spectrometry

Analysis of organic gunshot residue permeation through a model skin membrane using ion mobility spectrometry

Similar Documents

Transport modeling of membrane extraction of chlorinated hydrocarbon from water for ion mobility spectrometry

Medical applications of ion mobility spectrometry

Hydrocarbon detection using laser ion mobility spectrometry

Ion mobility spectrometry: a personal retrospective

Ion mobility spectrometer—field asymmetric ion mobility spectrometer-mass spectrometry

Alexandre A. Svartsburg: Differential Ion Mobility Spectrometry

Minimal retarded Propofol signals in human breath using ion mobility spectrometry

Subambient pressure electrospray ionization ion mobility spectrometry

An NO$^{+}$ reactant ion source for ion mobility spectrometry

Analysis of organic gunshot residue permeation through a model skin membrane using ion mobility spectrometry