NDLI: Ion mobility spectrometer—field asymmetric ion mobility spectrometer-mass spectrometry

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Ion mobility spectrometer—field asymmetric ion mobility spectrometer-mass spectrometry

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International Journal for Ion Mobility Spectrometry : Volume 13

International Journal for Ion Mobility Spectrometry : Volume 12

International Journal for Ion Mobility Spectrometry : Volume 11

Ion mobility spectrometer—field asymmetric ion mobility spectrometer-mass spectrometry

Content Provider	Springer Nature Link
Author	Pollard, Matthew J. Hilton, Christopher K. Li, Hongli Kaplan, Kimberly Yost, Richard A. Hill, Herbert H.
Copyright Year	2011
Abstract	Since the development of electrospray ionization (ESI) for ion mobility spectrometry mass spectrometry (IMMS), IMMS have been extensively applied for characterization of gas-phase bio-molecules. Conventional ion mobility spectrometry (IMS), defined as drift tube IMS (DT-IMS), is typically a stacked ring design that utilizes a low electric field gradient. Field asymmetric ion mobility spectrometry (FAIMS) is a newer version of IMS, however, the geometry of the system is significantly different than DT-IMS and data are collected using a much higher electric field. Here we report construction of a novel ambient pressure dual gate DT-IMS coupled with a FAIMS system and then coupled to a quadrupole ion trap mass spectrometer (QITMS) to form a hybrid three-dimensional separation instrument, DT-IMS-FAIMS-QITMS. The DT-IMS was operated at ~3 Townsend (electric field/number density (E/N) or (Td)) and was coupled in series with a FAIMS, operated at ~80 Td. Ions were mobility-selected by the dual gate DT-IMS into the FAIMS and from the FAIMS the ions were detected by the QITMS for as either MS or MS$^{n}$. The system was evaluated using cocaine as an analytical standard and tested for the application of separating three isomeric tri-peptides: tyrosine-glycine-tryptophan (YGW), tryptophan-glycine-tyrosine (WGY) and tyrosine-tryptophan-glycine (YWG). All three tri-peptides were separated in the DT-IMS dimension and each had one mobility peak. The samples were partially separated in the FAIMS dimension but two conformation peaks were detected for the YWG sample while YGW and WGY produced only one peak. Ion validation was achieved for all three samples using QITMS.
Starting Page	15
Ending Page	22
Page Count	8
File Format	PDF
ISSN	14356163
Journal	International Journal for Ion Mobility Spectrometry
Volume Number	14
Issue Number	1
e-ISSN	18654584
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-03-09
Publisher Place	Berlin, Heidelberg
Access Restriction	Subscribed
Subject Keyword	Ion mobility spectrometry Field asymmetric ion mobility spectrometry Peptide separation Ecotoxicology Molecular Medicine Proteomics Safety in Chemistry, Dangerous Goods Analytical Chemistry Physical Chemistry
Content Type	Text
Resource Type	Article
Subject	Spectroscopy

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