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| Content Provider | Springer Nature Link |
|---|---|
| Author | Li, Yanqin Han, Liang Xu, Ming Guo, Junjie Feng, Mali Wang, Xiaojiong |
| Copyright Year | 2013 |
| Abstract | In the first part of this paper, gut microbial difference of two genotypes mice was researched. The gut microbial community of type 2 diabetes animal model KKAy mice and normal C57BL/6J mice had clear distinctions in DGGE (denaturing gradient gel electrophoresis) profiles. The pairwise similarity coefficient (C $_{ s }$) was only 26–44 % between KKAy and C57BL/6J, but C $_{ s }$ was 82–100 % among same genotypes mice. Thirteen dominant bands were cloned from DGGE profiles to exhibit difference on gut microbial structure further. In the second part of this paper, the influence of hypoglycemic drug Pioglitazone on the gut microbes in KKAy mice was researched by gut microbial diversity analysis and principal component analysis (PCA). The results showed that Pioglitazone reduced the gut microbial diversity slightly and changed gut microbial structure of KKAy mice to that of normal C57BL/6J mice. |
| Starting Page | 12 |
| Ending Page | 19 |
| Page Count | 8 |
| File Format | |
| ISSN | 00468991 |
| Journal | Indian Journal of Microbiology |
| Volume Number | 54 |
| Issue Number | 1 |
| e-ISSN | 09737715 |
| Language | English |
| Publisher | Springer India |
| Publisher Date | 2013-04-28 |
| Publisher Institution | Association of Microbiologists of India |
| Publisher Place | India |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Gut microbes KKAy mice Type 2 diabetes Genotypes Pioglitazone Microbiology Medical Microbiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Microbiology |
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