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| Content Provider | Springer Nature Link |
|---|---|
| Author | Rabiw, Leonard Samson, Marie Laure |
| Copyright Year | 2010 |
| Abstract | DOA kinase, the Drosophila member of the LAMMER/Clk protein kinase family, phosphorylates SR and SR-like proteins, including TRA, TRA2 and RBP1, which are responsible for the alternative splicing of transcripts encoding the key regulator of sex-specific expression in somatic cells of the fly, DOUBLESEX. Specific Doa alleles induce somatic female-to-male sex transformations, which can be enhanced when combined with mutations in loci encoding SR and SR-like proteins. The Doa locus encodes six different kinases, of which a 69-kDa isoform is expressed solely in females. Expression of this isoform is itself under the regulation of the somatic sex determination regulatory network, thus forming a putative positive autoregulatory loop which would reinforce the choice of the female cell-fate. We speculate that this loop is part of the evolutionary ancestral sex-determination machinery, based upon evidence demonstrating the existence of an autoregulatory loop involving TRA and TRA2 in several other insect species. |
| Starting Page | 271 |
| Ending Page | 277 |
| Page Count | 7 |
| File Format | |
| ISSN | 00221333 |
| Journal | Journal of Genetics |
| Volume Number | 89 |
| Issue Number | 3 |
| e-ISSN | 09737731 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2010-09-06 |
| Publisher Institution | Indian Academy of Sciences |
| Publisher Place | India |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | phosphorylation alternative splicing SR proteins sex determination Evolutionary Biology Animal Genetics and Genomics Plant Genetics & Genomics Microbial Genetics and Genomics Life Sciences |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics |
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