NDLI: A search for additional X-linked genes affecting sex determination inDrosophila melanogaster

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Journal of Genetics : Volume 76

A search for additional X-linked genes affecting sex determination inDrosophila melanogaster

Content Provider	Springer Nature Link
Author	Anand, Anuranjan Dasgupta, Aindrilla Sudha, S. Raghavan, S. Chandra, H. Sharat
Copyright Year	1998
Abstract	The geneSex-lethal (Sxl) plays a pivotal role inDrosophila sexual development. Once activated in response to the X: A ratio signal in XX embryos,Sxl participates in appropriate implementation of all known aspects of sexual differentiation. We have attempted to identify new X-linked genes involved in sex determination, especially those involved in the regulation ofSxl. Since misregulation ofSxl, or that of the genes that regulate it, leads to female-specific lethality, or synergistic female-lethal gene interactions, or both, we used these criteria to screen about 10,000 EMS-treated chromosomes for (i) recessive female-specific lethality or (ii) enhanced female lethality intransheterozygous combination withSxl. Four potentially useful mutations—Sxldlf, fl-35, fl-46, 1–43—were recovered and a few of their properties were characterized. Approximate map positions of these mutations were determined by meiotic mapping. To understand their probable position(s) in the hierarchy of genes regulating sex determination, we studied dose-dependent interactions between them and mutations in genes known to affect sex determination by generating double and triple heterozygotes. These studies suggest that (i)Sxldlf is not defective in the ‘early’ regulation or functions ofSxl, and (ii)fl-35, fl-46 and1–43 are unlikely to be a part of the X: A ratio signal, i.e. they are not needed for the transcriptional activation ofSxl. On the other hand, they could be affecting post-transcriptional processing ofSxl transcripts.
Starting Page	27
Ending Page	36
Page Count	10
File Format	PDF
ISSN	00221333
Journal	Journal of Genetics
Volume Number	77
Issue Number	1
e-ISSN	09737731
Language	English
Publisher	Springer India
Publisher Date	1998-01-01
Publisher Institution	Indian Academy of Sciences
Publisher Place	New Delhi
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	sex determination dosage compensation Sex-lethal Drosophila melanogaster Life Sciences Microbial Genetics and Genomics Plant Genetics & Genomics Animal Genetics and Genomics Evolutionary Biology
Content Type	Text
Resource Type	Article
Subject	Genetics

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