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| Content Provider | Springer Nature Link |
|---|---|
| Author | KUMAR, AMIT MITRA, ATANU AJAY, AMRENDRA KUMAR BHAT, MANOJ KUMAR RAO, CHEBROLU P |
| Copyright Year | 2012 |
| Abstract | Binding of metal complexes of C2-glucosyl conjugates with DNA has been established by absorption and fluorescence studies. Conformational changes occurred in DNA upon binding have been studied by circular dichroism. All these studies are suggestive that the metal complexes bind to DNA through intercalation. Binding of di-nuclear copper complex 5 was found to be stronger when compared to the other complexes studied. Copper complexes were found to cleave the plasmid DNA in the absence of oxidizing or reducing agent, whereas, zinc complexes do not cleave. Metal complexes have shown toxicity to the HeLa and MCF–7 cell lines. Morphological studies, western blot and FACS analysis are suggestive of apoptotic cell death induced by the metal complexes. Di-nuclear copper complexes were found to be better as compared to the mononuclear ones in binding, plasmid cleavage and also in causing more cell death. Graphical Abstract Spectral studies primarily suggest that the complexes of C2-glucosyl conjugates bind to DNA through intercalation. Copper complexes were found to cleave the plasmid DNA as well showed toxicity to HeLa and MCF–7 cell lines, suggestive of apoptotic cell death. Dinuclear complexes do bind better than the mononuclear ones. |
| Starting Page | 1217 |
| Ending Page | 1228 |
| Page Count | 12 |
| File Format | |
| ISSN | 09743626 |
| Journal | Journal of Chemical Sciences |
| Volume Number | 124 |
| Issue Number | 6 |
| e-ISSN | 09737103 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2013-01-06 |
| Publisher Institution | Indian Academy of Sciences |
| Publisher Place | India |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Glyco-metal-complexes DNA cleavage cytotoxicity apoptosis Chemistry/Food Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry |
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