NDLI: Defective Autophagy in Parkinson’s Disease: Role of Oxidative Stress

Content Provider	Springer Nature Link
Author	Janda, Elzbieta Isidoro, Ciro Carresi, Cristina Mollace, Vincenzo
Copyright Year	2012
Abstract	Parkinson’s disease (PD) is a paradigmatic example of neurodegenerative disorder with a critical role of oxidative stress in its etiopathogenesis. Genetic susceptibility factors of PD, such as mutations in Parkin, PTEN-induced kinase 1, and DJ-1 as well as the exposure to pesticides and heavy metals, both contribute to altered redox balance and degeneration of dopaminergic neurons in the substantia nigra. Dysregulation of autophagy, a lysosomal-driven process of self degradation of cellular organelles and protein aggregates, is also implicated in PD and PD-related mutations, and environmental toxins deregulate autophagy. However, experimental evidence suggests a complex and ambiguous role of autophagy in PD since either impaired or abnormally upregulated autophagic flux has been shown to cause neuronal loss. Finally, it is generally believed that oxidative stress is a strong proautophagic stimulus. However, some evidence coming from neurobiology as well as from other fields indicate an inhibitory role of reactive oxygen species and reactive nitrogen species on the autophagic machinery. This review examines the scientific evidence supporting different concepts on how autophagy is dysregulated in PD and attempts to reconcile apparently contradictory views on the role of oxidative stress in autophagy regulation. The complex relationship between autophagy and oxidative stress is also considered in the context of the ongoing search for a novel PD therapy.
Starting Page	639
Ending Page	661
Page Count	23
File Format	PDF
ISSN	08937648
Journal	Molecular Neurobiology
Volume Number	46
Issue Number	3
e-ISSN	15591182
Language	English
Publisher	Humana Press Inc
Publisher Date	2012-08-17
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Autophagy Mitophagy ROS Rotenone Paraquat MPTP Neurology Neurosciences Cell Biology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Neurology Cellular and Molecular Neuroscience

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