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| Content Provider | Springer Nature Link |
|---|---|
| Author | Pilato, F. Profice, P. Ranieri, F. Capone, F. Iorio, R. Florio, L. Lazzaro, V. |
| Copyright Year | 2012 |
| Abstract | Several studies demonstrated in experimental models and in humans synaptic plasticity impairment in some neurodegenerative and neuropsychiatric diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and schizophrenia. Recently new neurophysiological tools, such as repetitive transcranial magnetic stimulation and transcranial direct current stimulation, have been introduced in experimental and clinical settings for studying physiology of the brain and modulating cortical activity. These techniques use noninvasive transcranial electrical or magnetic stimulation to modulate neurons activity in the human brain. Cortical stimulation might enhance or inhibit the activity of cortico–subcortical networks, depending on stimulus frequency and intensity, current polarity, and other stimulation parameters such as the configuration of the induced electric field and stimulation protocols. On this basis, in the last two decades, these techniques have rapidly become valuable tools to investigate physiology of the human brain and have been applied to treat drug-resistant neurological and psychiatric diseases. Here we describe these techniques and discuss the mechanisms that may explain these effects. |
| Starting Page | 563 |
| Ending Page | 571 |
| Page Count | 9 |
| File Format | |
| ISSN | 08937648 |
| Journal | Molecular Neurobiology |
| Volume Number | 46 |
| Issue Number | 3 |
| e-ISSN | 15591182 |
| Language | English |
| Publisher | Humana Press Inc |
| Publisher Date | 2012-07-22 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Transcranial magnetic stimulation Transcranial direct current stimulation Plasticity Alzheimer's disease Parkinson's disease Huntington's disease Neurology Neurosciences Cell Biology Neurobiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Cellular and Molecular Neuroscience |
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