NDLI: Phosphatidylinositol 4-Kinases and PI4P Metabolism in the Nervous System: Roles in Psychiatric and Neurological Diseases

Content Provider	Springer Nature Link
Author	Clayton, Emma L. Migue, Shane Waugh, Mark G.
Copyright Year	2012
Abstract	The four mammalian phosphatidylinositol 4-kinases, together with the PI(4,5)P$_{2}$ depleting 5-phosphatases of the oculocerebrorenal syndrome of Lowe and synaptojanin families, modulate neuronal pools of PI4P lipid and regulate intracellular membrane trafficking in the endocytic and secretory pathways. Dysfunctions in these enzymes have been associated with a broad spectrum of disorders including schizophrenia, bipolar disorder, Lowe syndrome, age-related neurodegeneration, Alzheimer’s disease and Down syndrome. Recent work has shown that reduced expression of individual phosphatidylinositol 4-kinase isozymes is associated with impaired survival of specific neuronal populations within the CNS. Furthermore, alterations to the concentrations of different phosphoinositide lipid species in the brain and, in particular, the ratio of PI4P to PI(4,5)P$_{2}$ can have deleterious effects on clathrin-dependent membrane trafficking both in the Golgi–endosomal pathway and at the plasma membrane. In this article, we focus on the cell biology, biochemistry and neuronal functions of the phosphatidylinositol 4-kinases and their emerging roles in psychiatric and neurological pathologies.
Starting Page	361
Ending Page	372
Page Count	12
File Format	PDF
ISSN	08937648
Journal	Molecular Neurobiology
Volume Number	47
Issue Number	1
e-ISSN	15591182
Language	English
Publisher	Humana Press Inc
Publisher Date	2012-10-10
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Phosphatidylinositol 4-Kinase Endosome Alzheimer’s Schizophrenia Down syndrome Clathrin 22q11 Golgi Neurosciences Neurobiology Cell Biology Neurology
Content Type	Text
Resource Type	Article
Subject	Neurology Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Study of GOLPH3: a Potential Stress-Inducible Protein from Golgi Apparatus

Upregulation of SET Expression by BACE1 and its Implications in Down Syndrome

Phagocytosis of Microglia in the Central Nervous System Diseases

The associations between plasma soluble Trem1 and neurological diseases: a Mendelian randomization study

phosphatidylinositol 4-kinases; PI4P,

Brain Insulin Dysregulation: Implication for Neurological and Neuropsychiatric Disorders

Metabolism of Phosphatidylinositol 4-Kinase IIIa-Dependent PI4P Is Subverted by HCV and Is Targeted by a 4-Anilino Quinazoline with Antiviral Activity

Altered neurological function in mice immunized with early endosome antigen 1

Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System

Phosphatidylinositol 4-Kinases and PI4P Metabolism in the Nervous System: Roles in Psychiatric and Neurological Diseases

Similar Documents

Study of GOLPH3: a Potential Stress-Inducible Protein from Golgi Apparatus

Upregulation of SET Expression by BACE1 and its Implications in Down Syndrome

Phagocytosis of Microglia in the Central Nervous System Diseases

The associations between plasma soluble Trem1 and neurological diseases: a Mendelian randomization study

phosphatidylinositol 4-kinases; PI4P,

Brain Insulin Dysregulation: Implication for Neurological and Neuropsychiatric Disorders

Metabolism of Phosphatidylinositol 4-Kinase IIIa-Dependent PI4P Is Subverted by HCV and Is Targeted by a 4-Anilino Quinazoline with Antiviral Activity

Altered neurological function in mice immunized with early endosome antigen 1

Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System

Phosphatidylinositol 4-Kinases and PI4P Metabolism in the Nervous System: Roles in Psychiatric and Neurological Diseases