NDLI: PACAP Immunoreactivity in Human Malignant Tumor Samples and Cardiac Diseases

Content Provider	Springer Nature Link
Author	Szanto, Z. Sarszegi, Zs. Reglodi, D. Nemeth, J. Szabadfi, K. Kiss, P. Varga, A. Banki, E. Csanaky, K. Gaszner, B. Pinter, O. Szalai, Zs. Tamas, A.
Copyright Year	2012
Abstract	Pituitary adenylate cyclase activating polypeptide (PACAP) is a pleiotropic and multifunctional neuropeptide having important roles in various physiological processes. Recent trends in PACAP research point to the clinical introduction of PACAP or its analogs/fragments possibly in the near future. Recently, we have shown the presence of PACAP in human plasma, milk, placenta, and follicular fluid samples. However, relatively few data are available on PACAP in human tissues from patients with different disorders. The aim of the present study was to determine, by radioimmunoassay, the tissue level of PACAP38-like immunoreactivity (LI) and PACAP27-LI in different primary non-small cell lung cancer, colon tumor samples, and in cardiac muscle samples from patients suffering from ischemic heart disease and valvular disorders. We also labeled the PAC1 receptors in human cardiac cells. All samples showed significantly higher PACAP38-LI compared with PACAP27-LI. We found significantly lower levels of PACAP38-LI and PACAP27-LI in tumoral and peripheral samples compared with normal healthy tissue in both lung and colon cancers. Further investigations are necessary to describe the exact function of PACAP in oncogenesis. We showed that PACAP38-LI and PACAP27-LI are significantly higher in ischemic heart diseases compared with valvular abnormalities, suggesting that PACAP might play a role in ischemic heart disorders.
Starting Page	667
Ending Page	673
Page Count	7
File Format	PDF
ISSN	08958696
Journal	Journal of Molecular Neuroscience
Volume Number	48
Issue Number	3
e-ISSN	15591166
Language	English
Publisher	Humana Press Inc
Publisher Date	2012-05-31
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	PACAP Colon cancer Lung cancer Heart disorder PAC1 receptor Neurosciences Neurochemistry Neurology Proteomics Cell Biology
Content Type	Text
Resource Type	Article
Subject	Medicine Cellular and Molecular Neuroscience

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