NDLI: Cannabinoid receptors and their role in neuroprotection

Content Provider	Springer Nature Link
Author	van der Stelt, Mario Marzo, Vincenzo
Copyright Year	2005
Abstract	Two G protein-coupled receptors for marijuana’s psychoactive component, Δ$^{9}$-tetrahydrocannabinol, have been cloned to date, the cannabinoid CB$_{1}$ and CB$_{2}$ receptors. These two proteins, the endogenous lipids that activate them, also known as endocannabinoids, and the proteins for the biosynthesis and inactivation of these ligands constitute the endocannabinoid system. Evidence has accumulated over the last few years suggesting that endocannabinoid-based drugs may potentially be useful to reduce the effects of neurodegeneration. In fact, exogenous and endogenous cannabinoids were shown to exert neuroprotection in a variety of in vitro and in vivo models of neuronal injury via different mechanisms, such as prevention of excitotoxicity by cannabinoid CB$_{1}$-mediated inhibition of glutamatergic transmission, reduction of calcium influx, anti-oxidant activity, activation of the phosphatidylinositol 3-kinase/protein kinase B pathway, induction of phosphorylation of extracellular regulated kinases and the expression of transcription factors and neurotrophins, lowering of cerebrovasoconstriction and induction of hypothermia. The release of endocannabinoids during neuronal injury may constitute a protective response. If this neuroprotective function of cannabinoid receptor activation can be transferred to the clinic, it might represent an interesting target to develop neuroprotective agents.
Starting Page	37
Ending Page	50
Page Count	14
File Format	PDF
ISSN	15351084
Journal	NeuroMolecular Medicine
Volume Number	7
Issue Number	1-2
e-ISSN	15591174
Language	English
Publisher	Humana Press
Publisher Date	2005-01-01
Publisher Place	Totowa
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Medicine/Public Health Neurology Internal Medicine
Content Type	Text
Resource Type	Article
Subject	Neurology Molecular Medicine Cellular and Molecular Neuroscience

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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