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Neurochemical Research : Volume 23, Issue 4, April 1998

Neurochemical Research : Volume 23, Issue 3, March 1998

Neurochemical Research : Volume 23, Issue 2, February 1998

Neurochemical Research : Volume 23, Issue 1, January 1998

Neurochemical Research : Volume 22

Cannabinoid Receptors and Their Endogenous Agonist, Anandamide

Content Provider	Springer Nature Link
Author	Axelrod, Julius Felder, Christian C.
Copyright Year	1998
Abstract	Cannabinoids are a class of compound found in marijuana which have been known for their therapeutic and psychoactive properties for at least 4000 years. Isolation of the active principle in marijuana, Δ9-THC, provided the lead structure in the development of highly potent congeners which were used to probe for the mechanism of marijuana action. Cannabinoids were shown to bind to selective binding sites in brain tissue thereby regulating second messenger formation. Such studies led to the cloning of three cannabinoid receptor subtypes, CB1, CB2, and CB1A all of which belong to the superfamily of G protein-coupled plasma membrane receptors. Analogous to the discovery of endogenous opiates, isolation of cannabinoid receptors provided the appropriate tool to isolate an endogenous cannabimimetic eicosanoid, anandamide, from porcine brain. Recent studies indicate that anandamide is a member of a family of fatty acid ethanolamides that may represent a novel class of lipid neurotransmitters. This review discusses recent progress in cannabinoid research with a focus on the receptors for Δ9-THC, their coupling to second messenger responses, and the endogenous lipid cannabimimetic, anandamide.
Starting Page	575
Ending Page	581
Page Count	7
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	23
Issue Number	5
e-ISSN	15736903
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	1998-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurosciences Neurology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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