NDLI: Recent developments in proteomics : Implications for the study of cardiac hypertrophy and failure

Content Provider	Springer Nature Link
Author	Faber, Matthijs J. Agnetti, Giulio Bezstarosti, Karel Lankhuizen, Inge M. Dalinghaus, Michiel Guarnieri, Carlo Caldarera, Claudio M. Helbing, Willem A. Lamers, Jos M. J.
Copyright Year	2006
Abstract	The key components to the molecular understanding of the pathophysiology of various forms of heart failure involve global and/or large-scale identifications of protiens, their patterns of expression, posttranslational modifications, and functional characterization. Particularly, proteins involved in the induction of cardiac (mal)adaptive hypertrophic growth, interstitial fibrosis, and contractile dysfunction are of interest. In general, with the accumulation of vast amounts of DNA sequences in databases, researchers have become aware that merely having complete sequences of genomes and transcriptional changes for thousands of genes simultaneously will not be sufficient to elucidate, in molecular terms, the etiology and pathophysiology of cardiovascular disease. In the last decade, a new technology called proteomics has become available that allows biological and (patho)physiological questions to be approached exclusively from the protein perspective. Proteomics may enable us to map the entire complement of protiens expressed by the heart at any time and condition. This approach creates the unique possibility to identifiy, by differential analysis, protien alterations associated with the etiology of heart disease and its progression, outcome, and response to therapy. To illustrate the true power of proteiomics, most of the currently available methodologies are first reviewed, including their limitations. This review also deals with the current status and the perspectives of proteomics applications in research on heart failure in general. Furthermore, examples of our recent data on global protein profiling of the pressure-overloaded rat right ventricle and of endothelin-1-stimulated cultrues of neonatal rat cardiac myocytes are provided. The last section is devoted to the continuous advances in proteomic technologies, including protein separation methods, mass spectrometric instrumentation, computational analysis, and bioinformatic tools, together with integrative databases.
Starting Page	11
Ending Page	29
Page Count	19
File Format	PDF
ISSN	10859195
Journal	Cell Biochemistry and Biophysics
Volume Number	44
Issue Number	1
e-ISSN	15590283
Language	English
Publisher	Humana Press
Publisher Date	2006-01-01
Publisher Place	Totowa
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biochemistry Pharmacology/Toxicology Biotechnology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Biochemistry Biophysics

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