NDLI: Correlations Between CT Perfusion Parameters and Vascular Endothelial Growth Factor Expression and Microvessel Density in Implanted VX2 Lung Tumors

Content Provider	Springer Nature Link
Author	Ling, Shoujia Deng, Dong Mo, Yan Zhang, Xiaobo Guan, Xuechun Wei, Qijun
Copyright Year	2014
Abstract	To evaluate the correlation between CT perfusion parameters and tumor angiogenesis, expression of VEGF is implanted in VX2 lung tumor. VX2 tumor cells were injected in 15 healthy New Zealand rabbits. After 20 days, tumors with diameter over 7 mm were scanned with 16 row spiral CT. Using Software Perfusion 3, blood flow (BF), blood volume (BV), permeability surface area product (PS), and the maximum attenuation value (MAV) were obtained. After CT examination, rabbit was sacrificed, and slices from tumor tissue were prepared and checked with immunohistochemical staining with anti-CD34 and anti-VEGF monoclonal antibodies. Correlation of CT perfusion parameters with MVD and VEGF expression was determined by using Pearson correlation analysis. Blood supply of tumor and regions around tumor was higher than that of normal lung tissue. PS value increased sharply in tumor tissue. PS value in regions around tumor was also higher than that of normal lung tissue but lower than that of tumor tissue. Significant positive correlation was observed between CT perfusion parameters (BF, BV, PS, and MAV) and expression of VEGF and MVD in tumor tissue. CT perfusion parameters provide reliable information of the microcirculation in tumor tissue; therefore, it can be used as indexes to characterize angiogenesis of tumor.
Starting Page	629
Ending Page	633
Page Count	5
File Format	PDF
ISSN	10859195
Journal	Cell Biochemistry and Biophysics
Volume Number	70
Issue Number	1
e-ISSN	15590283
Language	English
Publisher	Springer US
Publisher Date	2014-04-29
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	VX2 tumor CT perfusion VEGF MVD Tumor angiogenesis Biochemistry Pharmacology/Toxicology Biotechnology Cell Biology Biophysics and Biological Physics
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Biochemistry Biophysics

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