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| Content Provider | Springer Nature Link |
|---|---|
| Author | Tao, Yingqun Liang, Guobiao |
| Copyright Year | 2014 |
| Abstract | The aim of this study was to evaluate the clinical efficacy of deep brain stimulation (DBS) and subthalamic nuclei stimulation (STN) in the treatment of Parkinson’s disease. A total of 32 patients with Parkinson’s disease who continuously treated in our hospital with STN–DBS from November 2011 to November 2013 were selected. All the patients received follow-up evaluation, psychological status questionnaire survey and analysis before surgery and 3 months after surgery using unified Parkinson’s disease rating scale (UPDRS), Self-rating depression scale (SDS), and symptom checklist (SCL-90). After turned on the impulse generator (IPG), the daily activities and motor function of UPDRS in all the 32 cases of Parkinson’s disease patients were in “turn off” state; the mean improvement rates were 51.7 and 60.9 %; when the daily activities and motor function in the state of “turn on”, the mean improvement rates were 21.4 and 22.3 %. In 20 cases, the preoperative SDS > 50, the levels of depression, anxiety, somatization, interpersonal sensitivity, hostility, fear, and paranoia of SCL-90 were significant higher than the Chinese traditional levels (P < 0.05). Comparison of the preoperative and postoperative depression, somatization, fear, anxiety, and psychotic factor of SCL-90 found that there was negative correlation between preoperation and postoperation, and the differences were significant (P < 0.05), while there were no significant differences in interpersonal sensitivity and paranoia (P > 0.05). STN–DBS can improve the motor function and ability of daily life of Parkinson’s disease patients and can significantly improve the psychological condition of the patients with Parkinson’s disease and depression; it is a safe and effective method to the treatment of Parkinson’s disease. |
| Starting Page | 113 |
| Ending Page | 117 |
| Page Count | 5 |
| File Format | |
| ISSN | 10859195 |
| Journal | Cell Biochemistry and Biophysics |
| Volume Number | 71 |
| Issue Number | 1 |
| e-ISSN | 15590283 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2014-08-07 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Parkinson’s disease Deep brain stimulation Subthalamic nucleus Biochemistry Pharmacology/Toxicology Biotechnology Cell Biology Biophysics and Biological Physics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Biochemistry Biophysics |
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