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Glutathione-Related Antioxidant Defense System in Elderly Patients Treated for Hypertension

Content Provider	Springer Nature Link
Author	Rybka, J. Kupczyk, D. Kędziora Kornatowska, K. Motyl, J. Czuczejko, J. Szewczyk Golec, K. Kozakiewicz, M. Pawluk, H. Carvalho, L. A. Kędziora, J.
Copyright Year	2010
Abstract	The purpose of this study was to analyze glutathione antioxidant defense system in elderly patients treated for hypertension. Studies were carried out in the blood collected from 18 hypertensive and 15 age- and sex-matched controls, all subjects age over 60. Hypertensives were on their usual antihypertensive treatment at the time of blood collection. The concentration of glutathione (GSH) in whole blood and activities of glutathione peroxidase (GPx-1), glutathione transferase (GST), and glutathione reductase (GR) in erythrocytes were measured. The data from patients and controls were compared using independent-samples t test. P value of 0.05 and less was considered statistically significant. We observed increased glutathione-related antioxidant defense in treated hypertensive elderly patients (HT) when compared with healthy controls (C). Mean GSH concentration was significantly higher in HT when compared with C: 3.1 ± 0.29 and 2.6 ± 0.25 mmol/L, respectively, P < 0.001. Mean activity of GR was significantly higher in HT group if compared with C: 83.4 ± 15.25 U/g Hb versus 64.2 ± 8.26 U/g Hb, respectively, P < 0.001. Mean activity of GST was significantly higher in HT group compared with C: 3.0 ± 0.60 mmol CDNB-GSH/mgHb/min and 2.6 ± 0.36 mmol CDNB-GSH/mgHb/min, respectively, P < 0.05. No difference in GPx activity was observed between two groups. These results show that glutathione-related antioxidant defense system was enhanced in elderly hypertensive patients treated for their conditions. This suggests important role of glutathione system in blood pressure regulation. Alterations in concentration and activity of antioxidants observed during antihypertensive medication are likely to be related to the effect of the treatment on NO bioavailability.
Starting Page	1
Ending Page	9
Page Count	9
File Format	PDF
ISSN	15307905
Journal	Cardiovascular Toxicology
Volume Number	11
Issue Number	1
e-ISSN	15590259
Language	English
Publisher	Humana Press Inc
Publisher Date	2010-12-08
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hypertension Oxidative stress Nitrate stress Glutathione Glutathione reductase Glutathione peroxidase Glutathione transferase Cardiology Pharmacology/Toxicology
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Toxicology Cardiology and Cardiovascular Medicine

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Glutathione-Related Antioxidant Defense System in Elderly Patients Treated for Hypertension

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Glutathione-Related Antioxidant Defense System in Elderly Patients Treated for Hypertension

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Glutathione-Related Antioxidant Defense System in Elderly Patients Treated for Hypertension