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| Content Provider | Springer Nature Link |
|---|---|
| Author | Parveen, Adila Babbar, Rashmi Agarwal, Sarita Kotwani, Anita Fahim, Mohammad |
| Copyright Year | 2010 |
| Abstract | The present study demonstrated prophylactic and therapeutic potential of Terminalia arjuna bark extract in isoproterenol (ISO)-induced chronic heart failure (CHF). Fifteen days after injection of ISO (85 mg/kg twice at an interval of 24 h, s.c), rats showed decline in maximal rate of rise and fall of left ventricular pressure (LV (dP/dt)$_{max}$ and LV (dP/dt)$_{min}$), cardiac contractility index (LV (dP/dt)$_{max}$/LVP), cardiac output and rise in LV end-diastolic pressure. CHF rats showed a significant increase in serum creatine kinase isoenzyme-MB (CK-MB) and malondialdehyde levels, as well as fall in the activities of superoxide dismutase, reduced glutathione. Altered lipid profile and increased level of cytokine tumour necrosis factor-α (TNF-α) along with histological changes in heart were also observed in CHF rats. T. arjuna bark extract (500 mg/kg, p.o) treatment prior and 15 days after ISO injection significantly attenuated cardiac dysfunction and myocardial injury in CHF rats. Cardioprotective action of T. arjuna was comparable to fluvastatin, a synthetic drug. The results suggest that T. arjuna bark extract has a significant prophylactic and therapeutic beneficial effect on protection of heart against ISO-induced CHF possibly through maintaining endogenous antioxidant enzyme activities, inhibiting lipid peroxidation and cytokine levels. |
| Starting Page | 48 |
| Ending Page | 57 |
| Page Count | 10 |
| File Format | |
| ISSN | 15307905 |
| Journal | Cardiovascular Toxicology |
| Volume Number | 11 |
| Issue Number | 1 |
| e-ISSN | 15590259 |
| Language | English |
| Publisher | Humana Press Inc |
| Publisher Date | 2010-11-30 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Terminalia arjuna Isoproterenol Chronic heart failure Left ventricle functions Antioxidants Cytokine Cardiology Pharmacology/Toxicology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Molecular Biology Toxicology Cardiology and Cardiovascular Medicine |
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