NDLI: Modification of environmental toxicity by nutrients : Implications in atherosclerosis

Content Provider	Springer Nature Link
Author	Hennig, Bernhard Reiterer, Gudrun Majkova, Zuzana Oesterling, Elizabeth Meerarani, Purushothaman Toborek, Michal
Copyright Year	2005
Abstract	We hypothesize that nutrition can modulate the toxicity of environmental pollutants and thus modulate health and disease outcome associated with chemical insult. There is now increasing evidence that exposure to persistent organic pollutants, such as PCBs, can contribute to the development of inflammatory diseases such as atherosclerosis. Activation, chronic inflammation, and dysfunction of the vascular endothelium are critical events in the initiation and acceleration of a therosclerotic lesion formation. Our studies indicate that an increase in cellular oxidative stress and an imbalance in antioxidant status are critical events in PCB-mediated induction of inflammatory genes and endothelial cell dysfunction. Furthermore, we have found that specific dietary fats can further compromise endothelial dysfunction induced by selected PCBs and that antioxidant nutrients (such as vitamin E and dietary flavonoids) can protect against endothelial cell damage mediated by these persistent organic pollutants. Our recent data suggest that membrane lipid rafts such as caveolae may play a major role in the regulation of PCB-induced inflammatory signaling in endothelial cells. In addition, PCB-and lipid-induced inflammation can be down-regulated by ligands of anti-atherogenic peroxisome proliferatoractivated receptors (PPARs). We hypothesize that PCBs contribute to an endothelial inflammatory response in part by down-regulating PPAR signaling. Our data so far support our hypothesis that antioxidant nutrients and related bioactive compounds common in fruits and vegetables protect against environmental toxic insult to the vascular endothelium by down-regulation of signaling pathways involved in inflammatory responses and atherosclerosis. Even though the concept that nutrition may modify or ameliorate the toxicity of environmental chemicals is provocative and warrants further study, the implications for human health could be significant. More research is needed to understand observed interactions of PCB toxicity with nutritional interventions.
Starting Page	153
Ending Page	160
Page Count	8
File Format	PDF
ISSN	15307905
Journal	Cardiovascular Toxicology
Volume Number	5
Issue Number	2
e-ISSN	15590259
Language	English
Publisher	Humana Press
Publisher Date	2005-01-01
Publisher Place	Totowa
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Pharmacology/Toxicology Cardiology
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Toxicology Cardiology and Cardiovascular Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The role of phospholipases in lipid modification and atherosclerosis

Atherosclerosis and cancer : Flip sides of the neoplastic response in mammalian cells?

Questionable Conclusions in the Article “Cardiovascular Toxicity of Citrus aurantium in Exercised Rats”

Microtubules in cardiac toxicity and disease

AZT-Induced Oxidative Cardiovascular Toxicity: Attenuation by Mg-Supplementation

Environmental cardiovascular disease

Modified High-Density Lipoproteins by Artificial Sweetener, Aspartame, and Saccharin, Showed Loss of Anti-atherosclerotic Activity and Toxicity in Zebrafish

Differentiation-Dependent Doxorubicin Toxicity on H9c2 Cardiomyoblasts

Cardiovascular toxicities upon managanese exposure

Modification of environmental toxicity by nutrients : Implications in atherosclerosis

Similar Documents

The role of phospholipases in lipid modification and atherosclerosis

Atherosclerosis and cancer : Flip sides of the neoplastic response in mammalian cells?

Questionable Conclusions in the Article “Cardiovascular Toxicity of Citrus aurantium in Exercised Rats”

Microtubules in cardiac toxicity and disease

AZT-Induced Oxidative Cardiovascular Toxicity: Attenuation by Mg-Supplementation

Environmental cardiovascular disease

Modified High-Density Lipoproteins by Artificial Sweetener, Aspartame, and Saccharin, Showed Loss of Anti-atherosclerotic Activity and Toxicity in Zebrafish

Differentiation-Dependent Doxorubicin Toxicity on H9c2 Cardiomyoblasts

Cardiovascular toxicities upon managanese exposure

Modification of environmental toxicity by nutrients : Implications in atherosclerosis