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| Content Provider | Springer Nature Link |
|---|---|
| Author | Kocabay, Gonenc Karabay, Can Yucel Kalaycı, Arzu Oduncu, Vecih Akgun, Taylan Guler, Ahmet Kılıcgedik, Alev Kalkan, Sedat İzgi, Akin Kırma, Cevat |
| Copyright Year | 2014 |
| Abstract | Although the effects of chronic alcoholism on left ventricular (LV) systolic function are well established, diastolic impairment has been evaluated partially. In addition, there are scarce data available about the relation of LV diastolic function to either or both duration and quantity of drinking among alcoholics. The aim of the study was to evaluate the left atrial (LA) function in chronic asymptomatic alcoholic patients by using two-dimensional speckle-tracking echocardiography (2D-STE). We enrolled 30 healthy subjects (age 34.8 ± 5.8 years) and 75 asymptomatic male alcoholics (age 39.8 ± 6.5 years) divided into two groups, according to total lifetime dose of ethanol: group I, <15 kg/kg and group II, ≥15 kg/kg. In the 2D-STE analysis of the LA, strain during ventricular systole (LA-Res), during late diastole (LA-Pump) and strain rate during ventricular contraction (LA-SRs), during passive ventricular filling (LA-SRe), during active atrial contraction (LA-SRa) were obtained. Deceleration time was longer, E/A and V $_{p}$ were smaller, and E/E $_{m}$ was higher in alcoholics. Although parameters of diastolic dysfunction were comparable in alcoholic groups, LA-Res and LA-Pump were found significantly different among the alcoholics. However, there were no differences in LA-SRs and LA-SRe between the controls and alcoholic groups. LA function is reduced in chronic alcohol abuse, and heavy alcohol consumption may play an important role in LA function impairment. |
| Starting Page | 189 |
| Ending Page | 196 |
| Page Count | 8 |
| File Format | |
| ISSN | 15307905 |
| Journal | Cardiovascular Toxicology |
| Volume Number | 15 |
| Issue Number | 2 |
| e-ISSN | 15590259 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2014-09-23 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Left atrial function LV diastolic dysfunction Speckle-tracking echocardiography Chronic asymptomatic alcoholic patients Pharmacology/Toxicology Cardiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Molecular Biology Toxicology Cardiology and Cardiovascular Medicine |
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