NDLI: Sulfide Intoxication-Induced Circulatory Failure is Mediated by a Depression in Cardiac Contractility

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Sulfide Intoxication-Induced Circulatory Failure is Mediated by a Depression in Cardiac Contractility

Content Provider	Springer Nature Link
Author	Sobe, Takashi Haouzi, Philippe
Copyright Year	2015
Abstract	Hydrogen sulfide (H$_{2}$S) intoxication produces a rapid cardio-circulatory failure leading to cardiac arrest. In non-lethal forms of sulfide exposure, the presence of a circulatory shock is associated with long-term neurological sequelae. Our aim was to clarify the mechanisms of H$_{2}$S-induced circulatory failure. In anesthetized, paralyzed, and mechanically ventilated rats, cardiac output, arterial pressure and ventricular pressures were determined while NaHS was infused to increase arterial concentration of soluble H$_{2}$S (CgH$_{2}$S) from undetectable to levels leading to circulatory failure. Compared to control/saline infusion, blood pressure started to decrease significantly along with a modest drop in peripheral vascular resistance (−19 ± 5 %, P < 0.01), when CgH$_{2}$S reached about 1 μM. As CgH$_{2}$S exceeded 2–3 μM, parameters of ventricular contractility diminished with no further reduction in peripheral resistance. Whenever H$_{2}$S exposure was maintained at a higher level (CgH$_{2}$S over 7 μM), a severe depression of cardiac contractility was observed, leading to asystole within minutes, but with no evidence of peripheral vasoplegia. The immediate and long-term neurological effects of specifically counteracting sulfide-induced cardiac contractility depression following H$_{2}$S exposure remain to be investigated.
Starting Page	67
Ending Page	78
Page Count	12
File Format	PDF
ISSN	15307905
Journal	Cardiovascular Toxicology
Volume Number	16
Issue Number	1
e-ISSN	15590259
Language	English
Publisher	Springer US
Publisher Date	2015-01-24
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cardiac toxicity H$_{2}$S Vascular blood flow Vasodilation Pharmacology/Toxicology Cardiology
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Toxicology Cardiology and Cardiovascular Medicine

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