NDLI: Excess Dietary Vanadium Induces the Changes of Subsets and Proliferation of Splenic T Cells in Broilers

Content Provider	Springer Nature Link
Author	Cui, Wei Cui, Hengmin Peng, Xi Fang, Jing Zuo, Zhicai Liu, Xiaodong Wu, Bangyuan
Copyright Year	2010
Abstract	The purpose of this 42-day study was to investigate the effects of dietary excess vanadium on immune function by determining changes of the subsets and proliferation function of splenic T cells. Four hundred twenty 1-day-old avian broilers were divided into six groups and fed on a corn–soybean basal diet as control diet or the same diet amended to contain 5, 15, 30, 45, and 60 ppm of vanadium supplied as ammonium metavanadate. When compared with those of the control group, the percentage of CD3$^{+}$, CD3$^{+}$CD4$^{+}$, and CD3$^{+}$CD8$^{+}$ of splenic T cells were decreased in the 45 and 60 ppm groups; however, the percentage of CD3$^{+}$ and CD3$^{+}$CD4$^{+}$ were increased in the 5 ppm group, and the CD4+/CD8+ ratios were raised in the 5 and 15 ppm groups at 14 days of age. Meanwhile, the proliferation of splenic T cells were depressed in the 45 and 60 ppm groups but raised in the 5 and 15 ppm groups. Also, the serum interleukin-2 (IL-2) and interleukin-6 (IL-6) contents were decreased in the 45 and 60 ppm groups and increased in the 5 ppm group. It was concluded that dietary vanadium in excess of 30 ppm changed the percentages of splenic T cell subsets and inhibited the proliferation of splenic T cells and reduced the serum IL-2 and IL-6 contents. The cellular immune function was finally impaired in broilers.
Starting Page	932
Ending Page	938
Page Count	7
File Format	PDF
ISSN	01634984
Journal	Biological Trace Element Research
Volume Number	143
Issue Number	2
e-ISSN	15590720
Language	English
Publisher	Humana Press Inc
Publisher Date	2010-11-03
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Vanadium CD4+ CD8+ Proliferation Flow cytometry (FCM) IL-2 IL-6 Spleen Broiler Oncology Biotechnology Biochemistry Nutrition
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Endocrinology, Diabetes and Metabolism Clinical Biochemistry Biochemistry Inorganic Chemistry

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