NDLI: Influence of Primary Ligands (ODA, TDA) on Physicochemical and Biological Properties of Oxidovanadium (IV) Complexes with Bipy and Phen as Auxiliary Ligands

Content Provider	Springer Nature Link
Author	Pranczk, Joanna Tesmar, Aleksandra Wyrzykowski, Dariusz Inkielewicz Stępniak, Iwona Jacewicz, Dagmara Chmurzyński, Lech
Copyright Year	2016
Abstract	The influence of the oxydiacetate (ODA) and thiodiacetate (TDA) ligands on the physicochemical and biological properties of the oxidovanadium(IV) ternary complexes of the VO(L)(B) type, where L denotes ODA or TDA and B denotes 2,2′-bipyridine (bipy) or 1,10-phenanthroline (phen), has been investigated. The stability of the complexes in aqueous solutions, assessed based on the potentiometric titration method, increases in the following direction: VO(TDA)(bipy) < VO(ODA)(bipy) < VO(TDA)(phen) < VO(ODA)(phen). Furthermore, the influence of the TDA and ODA ligands on the antioxidant activity of the oxidovanadium(IV) complexes toward superoxide free radical (O$_{2}$ $^{•−}$), 2,2′-azinobis(3-ethylbenzothiazoline-6 sulfonic acid) cation radical (ABTS$^{+•}$) and 2,2-diphenyl-1-picrylhydrazyl radical (DPPH$^{•}$) has been examined and discussed. The reactivity of the complexes toward O$_{2}$ $^{•−}$ increases in the following direction: VO(TDA)(phen) < VO(TDA)(bipy) ≈ VO(ODA)(bipy) < VO(ODA)(phen). The antioxidant activity against ABTS$^{+•}$ and DPPH$^{•}$ free radicals is higher for phen complexes, whereas the thiodiacetate complexes are more reactive than are the corresponding oxydiacetate ones. Finally, herein, the cytoprotective activity of the complexes against the oxidative damage generated exogenously by hydrogen peroxide in the hippocampal neuronal HT22 cell line (the MTT and LDH tests) is reported. In a low concentration (1 μM), the cytoprotective action of thiodiacetate complexes is much higher than that of the corresponding oxydiacetate complexes. However, in the higher concentration range (10 and 100 μM), the antioxidant activity of the complexes is overcompensated by their cytotoxic effect.
Starting Page	251
Ending Page	258
Page Count	8
File Format	PDF
ISSN	01634984
Journal	Biological Trace Element Research
Volume Number	174
Issue Number	1
e-ISSN	15590720
Language	English
Publisher	Springer US
Publisher Date	2016-04-06
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Oxidovanadium(IV) Oxydiacetate Thiodiacetate Antioxidant activity Cytoprotective activity Hippocampal HT22 cells Biochemistry Biotechnology Nutrition Oncology
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Endocrinology, Diabetes and Metabolism Clinical Biochemistry Biochemistry Inorganic Chemistry

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