NDLI: In Vitro Toxicity Evaluation of 25-nm Anatase TiO$_{2}$ Nanoparticles in Immortalized Keratinocyte Cells

Content Provider	Springer Nature Link
Author	Chan, Jin Ying, Tang Guang, Yang F. Lin, Li X. Kai, Tang Fang, Zhang Y. Ting, Ye X. Xing, Lin F. Ji, Yang Y.
Copyright Year	2011
Abstract	Titanium dioxide (TiO$_{2}$) nanoparticles (NPs) are massively fabricated and widely used in daily life, and thus potential risk has been posed to human health. However, the mechanism of the interaction between TiO$_{2}$ NPs and cells is still unclear. In this study, the interaction of anatase TiO$_{2}$ NPs with HaCaT cells is studied in vitro with multi-techniques. The TiO$_{2}$ NPs not only insert into cells through endocytic pathway but also penetrate into the cell. The TiO$_{2}$ NPs could produce reactive oxygen species (ROS) after dispersion spontaneously. Furthermore, the interaction between TiO$_{2}$ NPs and cellular components might also generate ROS. The ROS generation could lead to cellular toxicity if the level of ROS production overwhelms the antioxidant defense. Cytoskeletal components, particularly the microfilaments and microtubules, cause modifications upon exposure to TiO$_{2}$ NPs. With all results, the toxicological effects of TiO$_{2}$ NPs on HaCaT cell can be simplified into six events.
Starting Page	183
Ending Page	196
Page Count	14
File Format	PDF
ISSN	01634984
Journal	Biological Trace Element Research
Volume Number	144
Issue Number	1-3
e-ISSN	15590720
Language	English
Publisher	Humana Press Inc
Publisher Date	2011-05-07
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	TiO$_{2}$ NPs Reactive oxygen species Cellular toxicity Transmission electron microscopy (TEM) Cytoskeleton Biochemistry Biotechnology Nutrition Oncology
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Endocrinology, Diabetes and Metabolism Clinical Biochemistry Biochemistry Inorganic Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cellular Toxicity of TiO$_{2}$ Nanoparticles in Anatase and Rutile Crystal Phase

Effect of Anatase Nanoparticles (TiO$_{2}$) on Parsley Seed Germination (Petroselinum crispum) In Vitro

Effects of Feeding Silkworm with Nanoparticulate Anatase TiO$_{2}$ (TiO$_{2}$ NPs) on Its Feed Efficiency

A multi-integrated approach on toxicity effects of engineered TiO$_{2}$ nanoparticles

Biochemical Toxicity of Nano-anatase TiO$_{2}$ Particles in Mice

Promotion of Energy Transfer and Oxygen Evolution in Spinach Photosystem II by Nano-anatase TiO$_{2}$

Nano-Anatase Relieves the Inhibition of Electron Transport Caused by Linolenic Acid in Chloroplasts of Spinach

The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles

Erratum to: Biochemical Toxicity of Nano-anatase TiO$_{2}$ Particles in Mice

In Vitro Toxicity Evaluation of 25-nm Anatase TiO$_{2}$ Nanoparticles in Immortalized Keratinocyte Cells

Similar Documents

Cellular Toxicity of TiO$_{2}$ Nanoparticles in Anatase and Rutile Crystal Phase

Effect of Anatase Nanoparticles (TiO$_{2}$) on Parsley Seed Germination (Petroselinum crispum) In Vitro

Effects of Feeding Silkworm with Nanoparticulate Anatase TiO$_{2}$ (TiO$_{2}$ NPs) on Its Feed Efficiency

A multi-integrated approach on toxicity effects of engineered TiO$_{2}$ nanoparticles

Biochemical Toxicity of Nano-anatase TiO$_{2}$ Particles in Mice

Promotion of Energy Transfer and Oxygen Evolution in Spinach Photosystem II by Nano-anatase TiO$_{2}$

Nano-Anatase Relieves the Inhibition of Electron Transport Caused by Linolenic Acid in Chloroplasts of Spinach

The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles

Erratum to: Biochemical Toxicity of Nano-anatase TiO$_{2}$ Particles in Mice

In Vitro Toxicity Evaluation of 25-nm Anatase TiO$_{2}$ Nanoparticles in Immortalized Keratinocyte Cells