NDLI: In Vitro Therapeutic Potential of Tio$_{2}$ Nanoparticles Against Human Cervical Carcinoma Cells

Content Provider	Springer Nature Link
Author	Pandurangan, Muthuraman Enkhtaivan, Gansukh Young, Jung A. Hoon, Hur Ji Lee, Hannah Lee, SooBin Kim, Doo Hwan
Copyright Year	2015
Abstract	Cellular and physiological responses to the degradation products of titanium implants are key indicators to determine the quality of biocompatibility of implant devices. The present study investigated titanium dioxide (TiO$_{2}$) nanoparticle-induced cytotoxicity, apoptotic morphological modification, and apoptotic-related gene expressions in the human cervical carcinoma cells. TiO$_{2}$ nanoparticle-induced cytotoxicity on cancer cells was determined by the sulphorhodamine-B assay. Apoptotic morphological modification such as nuclear fragmentation, rounding, cytoplasm shrinkage, loss of adhesion, and reduced cell volume were observed by an inverted, fluorescence, and confocal laser scanning microscope (CLSM). The DNA fragmentation study showed the occurrence of necrosis and apoptosis in nanoparticle-treated cells. The qPCR study showed the increased p53 and bax mRNA expression in the nanoparticle-treated cells compared to control. In addition, caspase 3 activity was increased in nanoparticle-treated cells, which indicates the increased auto-catalysis. Taking all these data together, it may suggest that TiO$_{2}$ nanoparticle could inhibit the growth of HeLa cells.
Starting Page	293
Ending Page	300
Page Count	8
File Format	PDF
ISSN	01634984
Journal	Biological Trace Element Research
Volume Number	171
Issue Number	2
e-ISSN	15590720
Language	English
Publisher	Springer US
Publisher Date	2015-10-31
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	TiO$_{2}$ nanoparticles HeLa cells Apoptosis mRNA SRB assay Caspase 3 Biochemistry Biotechnology Nutrition Oncology
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Endocrinology, Diabetes and Metabolism Clinical Biochemistry Biochemistry Inorganic Chemistry

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