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Localization and composition of renal immunodeposits in mice developing HgCl$_{2}$-induced autoimmune process

Content Provider	Springer Nature Link
Author	Arefieva, A. S. Dyban, P. A. Krasilshchikova, M. S. Dobrucki, J. W. Zatsepina, O. V.
Copyright Year	2010
Abstract	A characteristic feature of systemic autoimmune diseases, along with the appearance of autoantibodies that target self-antigenes, is the deposition of immunoglobulins and components of the complementary system in kidneys. However, the process of the development of a deposit and its cytotoxic effects still remain poorly studied. To elucidate these questions, we used SJL/J mice, which develop an autoimmune process accompanied by the appearance of anti-fibrillarin antibodies following regular administrations of sublethal dozes of HgCl$_{2}$. Using antibodies to total mouse immunoglobulins, we showed that immunodeposits are present in glomeruli of autoimmune and control (not-autoimmune) animals. The intensity of these antibodies was directly correlated with the titer of anti-fibrillarin autoantibodies and was minimal in control mice. Confocal microscopy and conventional fluorescence microscopy show that immunodeposits deeply penetrate glomeruli and are clearly identified within mesangial cells. Immunoglobulins fully colocolized with the C3-component of the complement, but not with fibrillarin, which is a major autoantigen. We failed to determine the signs of cell proliferation or death in glomeruli. The most prominent difference between control and autoimmune mice was the presence of immunodeposits in renal blood vessels. These observations argue in favor of the idea that destructive and dysfunctional renal lesions that accompany the development of autoimmune diseases can be caused in part by the accumulation of immunodeposits in blood vessels.
Starting Page	345
Ending Page	353
Page Count	9
File Format	PDF
ISSN	1990519X
Journal	Cell and Tissue Biology
Volume Number	4
Issue Number	4
e-ISSN	19905203
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2010-09-10
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	autoimmune pathologies immunodeposits kidney SJL/J mice strain HgCl$_{2}$ Cell Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology

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