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| Content Provider | Springer Nature Link |
|---|---|
| Author | Mityushova, E. V. Shatrova, A. N. Zenin, V. V. Aksev, N. D. Marakhova, I. I. |
| Copyright Year | 2013 |
| Abstract | A comparative study of STAT3 and STAT5 activity (assessed by tyrosine phosphorylation level) and the expression of an α-subunit of the interleukin-2 receptor (examined by cytophotometric evaluation of CD25 cell number) during phytohemaglutinin (PHA)-induced proliferation of human blood lymphocytes (HBLs) has been carried out. It was found that the level of STAT3 phosphorylation was high both in resting and competent HBLs and remained unchanged in the presence of PHA or interleukin-2 (IL-2). In contrast to STAT3, phosphorylation of STAT5 was not seen either in resting or competent HBL. In the presence of PHA, STAT5 phosphorylation was observed no earlier than in 2–5 h; maximal phosphorylation was detected after 24 h. In competent HBLs, exogenous IL-2 induced high phosphorylation of STAT5 in 30 min that was retained for the next 24–48 h. Alterations in the level of tyrosine phosphorylation of STAT5 correlated with CD25 expression. WHI-P131, a JAK3 kinase inhibitor, prevents STAT5 activation, CD25 surface expression, and lymphocyte proliferation. It is concluded that JAK3/STAT5 signaling via an IL-2 receptor is necessary to support the long-term expression of a high-affinity αβγ$_{c}$-receptor of IL-2 and HBL optimal proliferation. |
| Starting Page | 397 |
| Ending Page | 406 |
| Page Count | 10 |
| File Format | |
| ISSN | 1990519X |
| Journal | Cell and Tissue Biology |
| Volume Number | 7 |
| Issue Number | 5 |
| e-ISSN | 19905203 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2013-10-13 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | human lymphocytes STAT3 STAT5 interleukin-2 receptor α-subunit of interleukin-2 receptor CD25 JAK Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology |
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