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Left-ventricular heart aneurism as a new source of resident cardiac stem cells

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Left-ventricular heart aneurism as a new source of resident cardiac stem cells

Content Provider	Springer Nature Link
Author	Dergilev, K. V. Rubina, K. A. Tsokolaeva, Z. I. Sysoeva, V. Yu. Gmyzina, A. I. Kalinina, N. I. Belyavskaya, T. M. Akchurin, R. S. Parfeva, E. V. Tkachuk, V. A.
Copyright Year	2010
Abstract	In the past few years, it has been established that the heart contains a reservoir of stem and progenitor cells. These cells are able to differentiate in cardiomyogenic, endothelial, and smooth muscle lineages in vitro and in vivo and, following injection into an infarcted myocardium, these cells prevent the remodeling of the left ventricle and improve cardiac function. The aim of the present study was the immunophenotypic characterization of resident stem cells in the tissue of a chronic left aneurism, an analysis of their localization, and distribution in various aneurism areas.Fifteen samples of aneurism tissue obtained surgically were analyzed. The number of cells positive for c-kit stem-cell marker was about 3327 ± 234 cells per 1 cm$^{3}$ tissue. Single cells were found in fibrous, muscle, and adipose parts of aneurism tissue. Most of the cells were revealed in fibrous tissue near large vessels; however, the coexpression of c-kit and markers of endothelial cells was not observed. C-kit-positive cells did not express CD34 and CD45 markers and, thereby, were not of hematopoietic origin. The majority of c-kit-positive cells expressed MDR1, another stem-cell marker. These c-kit-positive cells did not proliferate, since they did not express Ki67. About 20% of these cells expressed an inhibitor of cyclin-dependent kinase p21$^{cip/Waf1}$. C-kit cells did not express markers of cardiomyocytes (Nkx 2.5, Gata 4, Mef2c, α-actinin), endothelium (Ets 1, CD105, wW), and smooth muscle cells (Gata 6, SMA). Single-cell clusters made up of 70–100 c-kit-positive cells (in cell niches) were observed; however, no markers of cardiomyogenic differentiation were expressed in these cells. Thus, aneurism tissue of the left ventricle contains c-kit-positive cells that, are most likely resident cardiac stem cells; however, their regenerative capacity should be further explored.
Starting Page	546
Ending Page	555
Page Count	10
File Format	PDF
ISSN	1990519X
Journal	Cell and Tissue Biology
Volume Number	4
Issue Number	6
e-ISSN	19905203
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2011-01-08
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	cardiac stem cells left ventricular aneurism c-kit-positive cells Cell Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology

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