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| Content Provider | Springer Nature Link |
|---|---|
| Author | Peng, Sikai Liu, Wanshun Han, Baoqin Chang, Jing Li, Minyu Zhi, Xuan |
| Copyright Year | 2011 |
| Abstract | Effects of carboxymethyl-chitosan with different molecular weights on wound healing were investigated in vivo and in vitro. A second degree burn model was performed in rats and the accelerative effects of carboxymethyl-chitosan on wound repair were observed. Contents of transforming growth factor (TGF)-β1, interleukin(IL)-6 and matrix metalloproteinase (MMP)-1 in wounds were determined by enzyme-linked immunosorbent assay (ELISA). In vitro study evaluated the influence of carboxymethyl-chitosan on cytokines secretion of fibroblasts and macrophages. In vivo results showed that carboxymethyl-chitosan effectively accelerated the wound healing process in burned rats (P<0.05). Levels of TGF-β1, IL-6 and MMP-1 in carboxymethyl-chitosan groups were significantly elevated, compared with control group (P<0.05). In vitro results indicated that carboxymethyl-chitosan significantly promoted the proliferation of fibroblasts and stimulated its IL-8 and IL-10 secretion at different incubation time, but it did not affect collagen secretion of fibroblasts. Carboxymethyl-chitosan enhanced phagocytosis ability of macrophages, and increased its tumor necrosis factor (TNF)-α secretion. In conclusion, carboxymethyl-chitosan promoted wound healing by activating macrophages, accelerating fibroblasts growth and exerting considerable effects on the secretion of a series of cytokines. |
| Starting Page | 369 |
| Ending Page | 378 |
| Page Count | 10 |
| File Format | |
| ISSN | 16725182 |
| Journal | Journal of Ocean University of China |
| Volume Number | 10 |
| Issue Number | 4 |
| e-ISSN | 19935021 |
| Language | English |
| Publisher | SP Science Press |
| Publisher Date | 2011-11-06 |
| Publisher Place | Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | carboxymethyl-chitosan wound healing fibroblasts macrophages cytokines Oceanography |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oceanography Ocean Engineering |
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