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| Content Provider | Springer Nature Link |
|---|---|
| Author | Batoy, S. Mariccor A. B. Borgmann, Sabine Flick, Karin Griffith, Josephine Jones, Jeffrey J. Saraswathi, Viswanathan Hasty, Alyssa H. Kaiser, Peter Wilkins, Charles L. |
| Copyright Year | 2008 |
| Abstract | Here we describe a study of the feasibility of lipid and phospholipid (PL) profiling using matrix assisted laser desorption/ionization (MALDI) Fourier transform mass spectrometry (FTMS) for two different applications. In this work PL profiles of different mammalian tissues as well as those of whole cell organisms were examined. In particular, comparative analysis of lipid and PL profiles of tissues from mice fed different diets was done and, in another application, MALDI FTMS was used to analyze PL profiles of genetically modified Saccharomyces cerevisiae. Computational sorting of the observed ions was done in order to group the lipid and PL ions from complex MALDI spectra. The PL profiles of liver tissues from mice fed different diets showed a cross correlation coefficient of 0.2580, indicating significant dissimilarity, and revealed more than 30 significantly different peaks at the 99.9% confidence level. Histogram plots derived from the spectra of wild type and genetically modified yeast resulted in a cross correlation coefficient 0.8941 showing greater similarity, but still revealing a number of significantly different peaks. Based on these results, it appears possible to use MALDI FTMS to identify PLs as potential biomarkers for metabolic processes in whole cells and tissues. |
| Starting Page | 367 |
| Ending Page | 371 |
| Page Count | 5 |
| File Format | |
| ISSN | 00244201 |
| Journal | Lipids |
| Volume Number | 44 |
| Issue Number | 4 |
| e-ISSN | 15589307 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2008-11-13 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Matrix assisted laser desorption/ionization mass spectrometry (MALDI) Fourier transform mass spectrometry (FTMS) Saccharomyces cerevisiae Yeast transcription factor Met4 High fat diet Microbial Genetics and Genomics Medicinal Chemistry Nutrition Medical Biochemistry Neurochemistry Lipidology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Organic Chemistry Biochemistry |
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