NDLI: Regulation of Steroid Hormone Biosynthesis by the Cytoskeleton

Content Provider	Springer Nature Link
Author	Sewer, Marion B. Li, Donghui
Copyright Year	2008
Abstract	Steroid hormones are synthesized in response to signaling cascades initiated by the trophic peptide hormones derived from the anterior pituitary. The mechanisms by which these peptide hormones regulate steroid hormone production are multifaceted and include controlling the transcription of steroidogenic genes, regulating cholesterol (substrate) uptake and transport, modulating steroidogenic enzyme activity, and controlling electron availability. Cytoskeletal polymers such as microfilaments and microtubules have also been implicated in regulating steroidogenesis. Of note, steroidogenesis is a multi-step process that occurs in two organelles, the endoplasmic reticulum (ER) and the mitochondrion. However, the precise mechanism by which substrates are delivered back and forth between these two organelles is unknown. In this review we will discuss the role of components of the cytoskeleton in conferring optimal steroidogenic potential. Finally, we present data that identifying a novel mechanism by which sphingosine-1-phosphate induces mitochondrial trafficking to promote steroidogenesis.
Starting Page	1109
Ending Page	1115
Page Count	7
File Format	PDF
ISSN	00244201
Journal	Lipids
Volume Number	43
Issue Number	12
e-ISSN	15589307
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-08-26
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Steroidogenesis Cortisol Progesterone Adrenocorticotropin Microtubules Microfilaments Sphingosine-1-phosphate Colchicine Taxol Microbial Genetics and Genomics Medicinal Chemistry Nutrition Medical Biochemistry Neurochemistry Lipidology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Organic Chemistry Biochemistry

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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